• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种在兔动物模型中使用基于羟基磷灰石-胶原蛋白混合植入物进行眶壁重建的新方法。

A New Approach for Orbital Wall Reconstruction in a Rabbit Animal Model Using a Hybrid Hydroxyapatite-Collagen-Based Implant.

作者信息

Vasile Victor A, Istrate Sinziana, Cursaru Laura-Madalina, Piticescu Roxana M, Ghita Aurelian M, Popescu Diana M, Garhöfer Gerhard, Catrina Ana M, Spandole-Dinu Sonia, Haidoiu Cerasela, Suhaianu Vladimir, Voinea Oana C, Dragut Dumitru Valentin, Popa-Cherecheanu Alina

机构信息

Department of Ophthalmology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Department of Ophthalmology, Ophtalmopôle, Hôpital Cochin, AP-HP, 75014 Paris, France.

出版信息

Int J Mol Sci. 2024 Nov 26;25(23):12712. doi: 10.3390/ijms252312712.

DOI:10.3390/ijms252312712
PMID:39684423
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11641411/
Abstract

Reconstructing the orbit following complex craniofacial fractures presents significant challenges. Throughout the years, several materials have been used for orbital reconstruction, taking into account factors such as their durability, compatibility with living tissue, cost efficiency, safety, and capacity to be adjusted during surgery. Nevertheless, a consensus has not yet been reached on the optimal material for orbital restoration. This study investigates the potential of a hybrid hydroxyapatite-collagen (HAp-COL) material 3D-printed on Ti mesh to be used as an implant for orbital wall reconstruction. HAp-COL powder was synthesized using a high-pressure hydrothermal technique. The powder was further used to 3D-print HAp-COL structures on titanium mesh, with the latter having potential uses in orbital wall reconstruction. Biocompatibility was assessed by evaluating the effects of the HAp-COL material on the adhesion and proliferation of fibroblasts (3T3) and mesenchymal stem cells (MSCs) in culture. In vitro and in vivo results showed that HAp-COL is highly biocompatible and has a good integration of the implant in the bone. The findings reported in this study offer convincing evidence to support the use of our designed HAp-COL for the restoration of orbital wall fractures, with a high level of safety.

摘要

复杂颅面骨折后的眼眶重建面临重大挑战。多年来，考虑到材料的耐久性、与活组织的相容性、成本效益、安全性以及手术中可调整性等因素，多种材料已被用于眼眶重建。然而，对于眼眶修复的最佳材料尚未达成共识。本研究调查了一种在钛网上3D打印的混合羟基磷灰石-胶原蛋白（HAp-COL）材料用作眼眶壁重建植入物的潜力。采用高压水热技术合成了HAp-COL粉末。该粉末进一步用于在钛网上3D打印HAp-COL结构，后者在眼眶壁重建中具有潜在用途。通过评估HAp-COL材料对培养中的成纤维细胞（3T3）和间充质干细胞（MSC）的黏附与增殖的影响来评估生物相容性。体外和体内结果表明，HAp-COL具有高度生物相容性，且植入物在骨中具有良好的整合性。本研究报告的结果提供了令人信服的证据，支持使用我们设计的HAp-COL进行眼眶壁骨折修复，安全性高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/780c709014c9/ijms-25-12712-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/334586da804c/ijms-25-12712-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/c942d9d42d7b/ijms-25-12712-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/a5fbe9cb5bfa/ijms-25-12712-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/32ecb1001b01/ijms-25-12712-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/ed4777b68ee3/ijms-25-12712-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/ef1b06db15c9/ijms-25-12712-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/78712af72e69/ijms-25-12712-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/79374a875741/ijms-25-12712-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/a39061bfa7fd/ijms-25-12712-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/82adaacaf908/ijms-25-12712-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/96cc9cfafe78/ijms-25-12712-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/30b9ecdc784a/ijms-25-12712-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/780c709014c9/ijms-25-12712-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/334586da804c/ijms-25-12712-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/c942d9d42d7b/ijms-25-12712-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/a5fbe9cb5bfa/ijms-25-12712-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/32ecb1001b01/ijms-25-12712-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/ed4777b68ee3/ijms-25-12712-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/ef1b06db15c9/ijms-25-12712-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/78712af72e69/ijms-25-12712-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/79374a875741/ijms-25-12712-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/a39061bfa7fd/ijms-25-12712-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/82adaacaf908/ijms-25-12712-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/96cc9cfafe78/ijms-25-12712-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/30b9ecdc784a/ijms-25-12712-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fe1/11641411/780c709014c9/ijms-25-12712-g013.jpg

相似文献

1
A New Approach for Orbital Wall Reconstruction in a Rabbit Animal Model Using a Hybrid Hydroxyapatite-Collagen-Based Implant.一种在兔动物模型中使用基于羟基磷灰石-胶原蛋白混合植入物进行眶壁重建的新方法。
Int J Mol Sci. 2024 Nov 26;25(23):12712. doi: 10.3390/ijms252312712.
2
Low-Cost 3D Printing Orbital Implant Templates in Secondary Orbital Reconstructions.二次眼眶重建中低成本3D打印眼眶植入模板
Ophthalmic Plast Reconstr Surg. 2017 Sep/Oct;33(5):376-380. doi: 10.1097/IOP.0000000000000884.
3
Generation of customized orbital implant templates using 3-dimensional printing for orbital wall reconstruction.使用 3D 打印技术生成定制化眶壁重建用眶内植入物模板。
Eye (Lond). 2018 Dec;32(12):1864-1870. doi: 10.1038/s41433-018-0193-1. Epub 2018 Aug 28.
4
Customized Orbital Wall Reconstruction Using Three-Dimensionally Printed Rapid Prototype Model in Patients With Orbital Wall Fracture.使用三维打印快速原型模型对眼眶壁骨折患者进行定制眼眶壁重建
J Craniofac Surg. 2016 Nov;27(8):2020-2024. doi: 10.1097/SCS.0000000000003195.
5
Technical concept of patient-specific, ultrahigh molecular weight polyethylene orbital wall implant.患者特异性超高相对分子质量聚乙烯眶壁植入物的技术概念。
J Craniomaxillofac Surg. 2013 Jun;41(4):282-90. doi: 10.1016/j.jcms.2012.10.007. Epub 2013 Jan 18.
6
Reconstruction of Combined Orbital Floor and Medial Wall Fractures Using Custom-Made Titanium Alloy Implant.使用定制钛合金植入物重建眼眶底壁和内侧壁联合骨折
J Craniofac Surg. 2021 Jun 1;32(4):e388-e389. doi: 10.1097/SCS.0000000000007392.
7
Repair of the Orbital Wall Fractures in Rabbit Animal Model Using Nanostructured Hydroxyapatite-Based Implant.使用纳米结构羟基磷灰石基植入物修复兔动物模型眼眶壁骨折
Nanomaterials (Basel). 2016 Jan 7;6(1):11. doi: 10.3390/nano6010011.
8
Clinical effects of 3-D printing-assisted personalized reconstructive surgery for blowout orbital fractures.3D打印辅助个性化重建手术治疗眼眶爆裂性骨折的临床效果
Graefes Arch Clin Exp Ophthalmol. 2017 Oct;255(10):2051-2057. doi: 10.1007/s00417-017-3766-y. Epub 2017 Aug 7.
9
Customized Titanium Mesh Based on the 3D Printed Model vs. Manual Intraoperative Bending of Titanium Mesh for Reconstructing of Orbital Bone Fracture: A Randomized Clinical Trial.基于3D打印模型定制钛网与术中手动弯曲钛网重建眼眶骨折的随机临床试验
Rev Recent Clin Trials. 2017;12(3):154-158. doi: 10.2174/1574887112666170821165206.
10
Alloplastic implants for orbital wall reconstruction.用于眶壁重建的异体植入物。
Facial Plast Surg. 2000;16(1):63-8. doi: 10.1055/s-2000-7327.

本文引用的文献

1
Organic-Inorganic Biocompatible Coatings for Temporary and Permanent Metal Implants.用于临时和永久金属植入物的有机-无机生物相容涂层。
Int J Mol Sci. 2024 Oct 29;25(21):11623. doi: 10.3390/ijms252111623.
2
The Deposition of Hydroxyapatite Particles Within an Organic Matrix on the Surface of Poly(lactic acid).羟基磷灰石颗粒在聚乳酸表面的有机基质中的沉积。
Int J Mol Sci. 2024 Oct 29;25(21):11587. doi: 10.3390/ijms252111587.
3
The Addition of Hydroxyapatite Nanoparticles on Implant Surfaces Modified by Zirconia Blasting and Acid Etching to Enhance Peri-Implant Bone Healing.
在氧化锆喷砂酸蚀处理改性的种植体表面添加羟基磷灰石纳米颗粒以增强种植体周围骨愈合。
Int J Mol Sci. 2024 Jul 3;25(13):7321. doi: 10.3390/ijms25137321.
4
An Overview on the Big Players in Bone Tissue Engineering: Biomaterials, Scaffolds and Cells.骨组织工程中的主要参与者概述：生物材料、支架和细胞。
Int J Mol Sci. 2024 Mar 29;25(7):3836. doi: 10.3390/ijms25073836.
5
Titanium Implants Coated with Hydroxyapatite Used in Orbital Wall Reconstruction-A Literature Review.用于眼眶壁重建的羟基磷灰石涂层钛植入物——文献综述
Materials (Basel). 2024 Apr 5;17(7):1676. doi: 10.3390/ma17071676.
6
FTIR-based prediction of collagen content in hydrolyzed protein samples.基于傅里叶变换红外光谱法的水解蛋白样品中胶原蛋白含量的预测。
Spectrochim Acta A Mol Biomol Spectrosc. 2023 Nov 15;301:122919. doi: 10.1016/j.saa.2023.122919. Epub 2023 May 30.
7
Retinal morphological and functional response to Idebenone therapy in Leber hereditary optic neuropathy.利伯遗传性视神经病变中艾地苯醌治疗的视网膜形态和功能反应。
Rom J Morphol Embryol. 2022 Jan-Mar;63(1):213-219. doi: 10.47162/RJME.63.1.24.
8
Biocompatible Materials for Orbital Wall Reconstruction-An Overview.用于眼眶壁重建的生物相容性材料——综述
Materials (Basel). 2022 Mar 16;15(6):2183. doi: 10.3390/ma15062183.
9
Collagen maturity and mineralization in mesenchymal stem cells cultured on the hydroxyapatite-based bone scaffold analyzed by ATR-FTIR spectroscopic imaging.通过衰减全反射傅里叶变换红外光谱成像分析在羟基磷灰石基骨支架上培养的间充质干细胞中的胶原蛋白成熟度和矿化情况。
Mater Sci Eng C Mater Biol Appl. 2021 Feb;119:111634. doi: 10.1016/j.msec.2020.111634. Epub 2020 Oct 16.
10
Customized Titanium Reconstruction of Orbital Fractures Using a Mirroring Technique for Virtual Reconstruction and 3D Model Printing.采用镜像技术对眼眶骨折进行定制钛重建，实现虚拟重建和 3D 模型打印。
J Oral Maxillofac Surg. 2021 Jan;79(1):200.e1-200.e9. doi: 10.1016/j.joms.2020.09.001. Epub 2020 Sep 6.