Guay A T, Spark R F, Jacobson J, Murray F T, Geisser M E
Center for Sexual Function, Lahey Clinic Northshore, Peabody, Massachusetts 01960, USA.
Int J Impot Res. 2002 Feb;14(1):25-31. doi: 10.1038/sj.ijir.3900803.
Yohimbine has had questionable effects in men with organic erectile dysfunction. We conducted this study to better define the population of men responsive to yohimbine, because tobacco was thought to affect a regimen of yohimbine more than other risk factors. We measured nocturnal penile tumescence with the RigiScan monitor, hormone profiles, answers to the Florida Sexual Health Questionnaire, and clinical responses at baseline and after two different doses of yohimbine in 18 nonsmoking men with erectile dysfunction. Of the 18 men, nine (50%) were successful in completing intercourse in more than 75% of attempts. The yohimbine responders were men with less severe erectile dysfunction as manifested by improved increased rigidity on RigiScan testing, higher Florida Sexual Health Questionnaire scores, and slightly higher levels of serum testosterone. Yohimbine is an effective therapy to treat organic erectile dysfunction in some men with erectile dysfunction.
育亨宾对患有器质性勃起功能障碍的男性的疗效存在争议。我们开展这项研究是为了更好地界定对育亨宾有反应的男性群体，因为据认为烟草对育亨宾治疗方案的影响大于其他风险因素。我们使用RigiScan监测仪测量了18名患有勃起功能障碍的非吸烟男性在基线时以及服用两种不同剂量育亨宾后的夜间阴茎胀大情况、激素水平、对佛罗里达性健康问卷的回答以及临床反应。在这18名男性中，有9名（50%）在超过75%的性交尝试中成功完成性交。育亨宾反应者是勃起功能障碍较轻的男性，表现为RigiScan测试中硬度增加、佛罗里达性健康问卷得分较高以及血清睾酮水平略高。育亨宾是治疗某些患有勃起功能障碍男性的器质性勃起功能障碍的有效疗法。
