Appleton R S, Victorica B E, Tamer D, Ayoub E M
J Lab Clin Med. 1985 Jan;105(1):114-9.
The specificity of the persistence of antibody to the streptococcal group A carbohydrate for mitral valve disease induced by rheumatic fever was examined. Levels of the antibody were determined in serum samples of 30 patients with rheumatic mitral insufficiency, 30 patients with mitral valve prolapse, and an equal number of normal individuals and patients with congenital heart disease. Antistreptolysin titers and anti-deoxyribonuclease B titers were also assayed in all sera. There were no differences in the incidence of elevated antibody titers or in the geometric means of the antibody titers for the normal individuals, the patients with congenital heart disease, and the patients with mitral valve prolapse. In contrast, the frequency of elevated anti-streptococcal group A carbohydrate titers and the geometric means of these titers were significantly higher in the patients with rheumatic mitral valve disease than in patients with mitral valve prolapse. This confirms the specificity of the persistent elevation of anti-streptococcal group A carbohydrate to patients with mitral valve disease induced by rheumatic fever and also suggests that the persistence of this antibody in patients with rheumatic valvular disease is not a result of a functional abnormality of the mitral valve.
对风湿热所致二尖瓣疾病中抗A组链球菌碳水化合物抗体持续存在的特异性进行了研究。测定了30例风湿性二尖瓣关闭不全患者、30例二尖瓣脱垂患者以及数量相等的正常人和先天性心脏病患者血清样本中的抗体水平。还对所有血清进行了抗链球菌溶血素滴度和抗脱氧核糖核酸酶B滴度检测。正常个体、先天性心脏病患者和二尖瓣脱垂患者中抗体滴度升高的发生率以及抗体滴度的几何平均值均无差异。相比之下，风湿性二尖瓣疾病患者中抗A组链球菌碳水化合物滴度升高的频率及其几何平均值显著高于二尖瓣脱垂患者。这证实了抗A组链球菌碳水化合物持续升高对风湿热所致二尖瓣疾病患者的特异性，也表明风湿性瓣膜病患者中该抗体的持续存在并非二尖瓣功能异常的结果。
