Tapazoglou E, Prasad A S, Hill G, Brewer G J, Kaplan J
J Lab Clin Med. 1985 Jan;105(1):19-22.
Zinc deficiency is associated with depression of a number of immune responses. To assess the relationship of zinc and natural killer activity, we studied natural killer activity in adults with sickle cell disease and in two normal volunteers rendered zinc deficient by dietary restriction. Natural killer activity was significantly lower in patients with sickle cell disease and zinc deficiency (5.1 +/- 2.9 lytic units per 10(6) cells) than in controls (11.7 +/- 5.0 lytic units per 10(6) cells). In the two volunteers, natural killer activity declined during zinc restriction and returned to near initial levels with zinc repletion. These results suggest that zinc deficiency is associated with a lowering of natural killer activity.
锌缺乏与多种免疫反应的抑制有关。为评估锌与自然杀伤细胞活性的关系，我们研究了镰状细胞病成人患者以及两名通过饮食限制导致锌缺乏的正常志愿者的自然杀伤细胞活性。镰状细胞病且锌缺乏患者的自然杀伤细胞活性（每10⁶个细胞5.1±2.9个裂解单位）显著低于对照组（每10⁶个细胞11.7±5.0个裂解单位）。在这两名志愿者中，自然杀伤细胞活性在锌限制期间下降，并在锌补充后恢复到接近初始水平。这些结果表明锌缺乏与自然杀伤细胞活性降低有关。
