Prasad A S, Kaplan J, Brewer G J, Dardenne M
Department of Medicine, Harper Grace Hospital, Detroit, Michigan.
Prog Clin Biol Res. 1989;319:629-47; discussion 648-9.
Zinc deficiency occurs frequently in SCA subjects. Our studies have shown that several parameters of cellular immune functions may be altered in SCA subjects and related to a deficiency of zinc. These include anergy to certain common antigens, which was reversible following zinc supplementation, decreased activity of natural killer (NK) cells, decreased production of interleukin (IL-2), decreased T4/T8 ratio and serum thymulin. Inasmuch as we have observed similar immunological changes in human volunteers (non-SCA) in whom we restricted only zinc intake and produced a mild specific deficiency of zinc, we conclude that the above changes in SCA were due to zinc deficiency. Although it is well known that susceptibility to infections is a common problem in SCA subjects, the pattern of infections related to cell mediated immune dysfunction has not been well documented. Whether or not supplementation with zinc will alter the pattern of infection and decrease morbidity in SCA on a long-term basis remains to be determined.
锌缺乏在镰状细胞贫血（SCA）患者中经常出现。我们的研究表明，SCA患者的一些细胞免疫功能参数可能会发生改变，且与锌缺乏有关。这些包括对某些常见抗原的无反应性，补充锌后这种情况可逆转；自然杀伤（NK）细胞活性降低；白细胞介素（IL-2）产生减少；T4/T8比值降低以及血清胸腺素减少。由于我们在仅限制锌摄入并导致轻度特异性锌缺乏的人类志愿者（非SCA患者）中观察到了类似的免疫变化，我们得出结论，SCA中的上述变化是由锌缺乏引起的。虽然众所周知，感染易感性是SCA患者的常见问题，但与细胞介导的免疫功能障碍相关的感染模式尚未得到充分记录。长期补充锌是否会改变SCA患者的感染模式并降低发病率仍有待确定。
