Ma Yuanyuan, Roeder Thomas
Nantong Key Laboratory of Environmental Toxicology, Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China.
Zoological Institute, Molecular Physiology, Kiel University, Olshausenstrasse 40, 24098 Kiel, Germany.
Int J Mol Sci. 2024 Dec 5;25(23):13092. doi: 10.3390/ijms252313092.
is gaining increasing recognition as a model organism for toxicological studies in marine ecosystems and expands the range of simple animal models currently used. Water pollution caused by human activities not only endangers environmental integrity but also affects human health, underlining the need to monitor water pollution effectively. This review describes the distinctive characteristics of , including its rapid reproductive cycle, increased sensitivity to environmental variability, and remarkable regenerative abilities. Over the last thirty years, has been used in various research areas, particularly molecular biology and toxicology. This endeavor has benefited from significant advances in genome and transcriptome technologies. Recent investigations have revealed its sensitivity to various pollutants and highlighted its potential for assessing toxicological effects at the physiological and molecular levels. Furthermore, the ecological versatility and stable microbiome of make it an exemplary model for research into pollutant interactions in marine ecosystems. Despite challenges associated with its complex genomic architecture, ongoing genomic efforts are promising to significantly enhance its utility in toxicological research. This review underscores the pivotal role of in advancing environmental health studies and outlines future research directions to maximize its potential as a model organism.
作为海洋生态系统毒理学研究的模式生物正日益受到认可,并扩展了目前使用的简单动物模型的范围。人类活动造成的水污染不仅危及环境完整性,还影响人类健康,这凸显了有效监测水污染的必要性。本综述描述了……的独特特征,包括其快速的繁殖周期、对环境变化的更高敏感性以及显著的再生能力。在过去三十年里,……已被用于各种研究领域,特别是分子生物学和毒理学。这一努力受益于基因组和转录组技术的重大进展。最近的研究揭示了它对各种污染物的敏感性,并突出了其在生理和分子水平评估毒理学效应的潜力。此外,……的生态多样性和稳定的微生物群落使其成为研究海洋生态系统中污染物相互作用的典范模型。尽管其复杂的基因组结构带来了挑战,但正在进行的基因组研究有望显著提高其在毒理学研究中的效用。本综述强调了……在推进环境健康研究中的关键作用,并概述了未来的研究方向,以最大限度地发挥其作为模式生物的潜力。 (注:原文中多次出现未明确指出的生物名称,用“……”代替)