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橙皮素可延长寿命并提高抗氧化能力，这与慢性氧化应激中IIS、HSP、线粒体未折叠蛋白反应（mtUPR）和JNK信号通路相关。

Hesperetin Increases Lifespan and Antioxidant Ability Correlating with IIS, HSP, mtUPR, and JNK Pathways of Chronic Oxidative Stress in .

作者信息

Wang Run-Jia, Ni Ya-Jing, Liu Yan-Qiang

机构信息

College of Life Sciences, Nankai University, Tianjin 300071, China.

出版信息

Int J Mol Sci. 2024 Dec 6;25(23):13148. doi: 10.3390/ijms252313148.

DOI:10.3390/ijms252313148
PMID:39684858
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11642050/
Abstract

Hesperetin (Hst) is a common citrus fruit flavonoid with antioxidant, anti-inflammatory, and anti-neurodegenerative effects. To explore the antioxidant and anti-aging effects and mechanisms of Hst, we induced chronic oxidative stress in using low-concentration HO and examined its effects on lifespan, healthy life index, reactive oxygen species (ROS), antioxidant enzymes, and transcriptomic metrics. Hst significantly prolonged lifespan, increased body bending and pharyngeal pumping frequency, decreased ROS accumulation, and increased antioxidant enzyme activity in normal and stressed . Hst significantly upregulated , , , , , , , , , and and downregulated and mRNAs in stressed . These genes are involved in the insulin/insulin-like growth factor-1 signaling (IIS), heat shock protein (HSP), mitochondrial unfolded protein response (mtUPR), and c-Jun N-terminal kinase (JNK) pathways. In summary, Hst increases lifespan and antioxidant ability, correlating with these pathways, during chronic oxidative stress in .

摘要

橙皮素（Hst）是一种常见的柑橘类水果黄酮，具有抗氧化、抗炎和抗神经退行性作用。为了探究Hst的抗氧化和抗衰老作用及机制，我们使用低浓度过氧化氢在[具体生物]中诱导慢性氧化应激，并检测其对寿命、健康生活指数、活性氧（ROS）、抗氧化酶和转录组指标的影响。Hst显著延长了[具体生物]在正常和应激状态下的寿命，增加了身体弯曲和咽部抽动频率，减少了ROS积累，并提高了抗氧化酶活性。在应激状态下的[具体生物]中，Hst显著上调了[一系列基因名称]的mRNA水平，下调了[另外两个基因名称]的mRNA水平。这些基因参与胰岛素/胰岛素样生长因子-1信号通路（IIS）、热休克蛋白（HSP）、线粒体未折叠蛋白反应（mtUPR）和c-Jun氨基末端激酶（JNK）通路。总之，在[具体生物]的慢性氧化应激过程中，Hst增加了寿命和抗氧化能力，这与这些通路相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6f3/11642050/db60eee8cc9b/ijms-25-13148-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6f3/11642050/50fc8c245789/ijms-25-13148-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6f3/11642050/db60eee8cc9b/ijms-25-13148-g008.jpg

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