Hsu Tzu-Chieh, Chiang Chun-Hsien, Liu I-Hsuan, Wang Chih-Yun, Chen Ching-Yi
Department of Animal Science and Technology, National Taiwan University, Taipei 10672, Taiwan.
Int J Mol Sci. 2024 Dec 9;25(23):13225. doi: 10.3390/ijms252313225.
Weight regain within one year after weight loss is frequently observed and is referred to as yo-yo dieting or weight cycling. In this study, we explore the effects of yo-yo dieting on the liver, adipose tissue, and muscle characteristics of male zebrafish. Four-month-old AB wild-type male zebrafish were randomly assigned to three groups: high-calorie intake (H, seven meals per day), low-calorie intake (L, two meals per day), and yo-yo diet (the low- and high-calorie alternation switched every two weeks) groups. Feeding the fish the H diet for over 8 weeks led to steatosis and damage to the liver. The yo-yo diet reduced liver lipid accumulation at week eight but caused a similar degree of lipid accumulation as the H diet thereafter. It was found that twenty weeks of yo-yo dieting actually exacerbated hepatic damage. Compared to the L diet, feeding the fish on the yo-yo and H diets for a period of 20 weeks significantly increased the size of muscle fibers, resulting in higher speed during burst swimming and a significant increase in the size and number of adipocytes in the abdominal tissue. To summarize, short-term yo-yo dieting was found to attenuate hepatosteatosis and maintain fast-twitch muscle function. Long-term yo-yo dieting preserved fast-twitch muscle function and muscle fiber size; however, it exacerbated the pathological changes in the liver.
减肥后一年内体重反弹的情况屡见不鲜，这被称为溜溜球节食或体重循环。在本研究中，我们探究了溜溜球节食对雄性斑马鱼肝脏、脂肪组织和肌肉特征的影响。将四个月大的AB野生型雄性斑马鱼随机分为三组：高热量摄入组（H，每天七餐）、低热量摄入组（L，每天两餐）和溜溜球节食组（低热量和高热量摄入每两周交替一次）。给鱼喂食H饮食超过8周会导致肝脏脂肪变性和损伤。溜溜球节食在第8周时减少了肝脏脂质积累，但此后导致的脂质积累程度与H饮食相似。研究发现，20周的溜溜球节食实际上加剧了肝脏损伤。与L饮食相比，给鱼喂食溜溜球节食和H饮食20周后，显著增加了肌肉纤维的大小，导致爆发式游泳时速度更快，腹部组织中脂肪细胞的大小和数量也显著增加。总之，发现短期溜溜球节食可减轻肝脏脂肪变性并维持快肌功能。长期溜溜球节食可保留快肌功能和肌肉纤维大小；然而，它加剧了肝脏的病理变化。
