Department of Cell Biology, Oita University Faculty of Medicine, Yufu 879-5593, Oita, Japan.
Cells. 2023 Sep 11;12(18):2246. doi: 10.3390/cells12182246.
Liver diseases represent a significant global health challenge, thereby necessitating extensive research to understand their intricate complexities and to develop effective treatments. In this context, zebrafish () have emerged as a valuable model organism for studying various aspects of liver disease. The zebrafish liver has striking similarities to the human liver in terms of structure, function, and regenerative capacity. Researchers have successfully induced liver damage in zebrafish using chemical toxins, genetic manipulation, and other methods, thereby allowing the study of disease mechanisms and the progression of liver disease. Zebrafish embryos or larvae, with their transparency and rapid development, provide a unique opportunity for high-throughput drug screening and the identification of potential therapeutics. This review highlights how research on zebrafish has provided valuable insights into the pathological mechanisms of human liver disease.
肝脏疾病是全球性的重大健康挑战，因此需要广泛的研究来了解其复杂的机制，并开发有效的治疗方法。在这方面，斑马鱼（）已成为研究肝脏疾病各个方面的一种有价值的模式生物。斑马鱼的肝脏在结构、功能和再生能力方面与人类肝脏有惊人的相似之处。研究人员已经成功地使用化学毒素、基因操作等方法在斑马鱼中诱导肝损伤，从而可以研究疾病机制和肝脏疾病的进展。斑马鱼胚胎或幼虫具有透明性和快速发育的特点，为高通量药物筛选和潜在治疗药物的鉴定提供了独特的机会。本综述强调了斑马鱼研究如何为人类肝脏疾病的病理机制提供了有价值的见解。
