The observational study investigates how personality factors influence depression, prenatal attachment, and fear of COVID-19 in women with high-risk pregnancies. Women experiencing a high-risk pregnancy between the 20th and 24th weeks of gestation (N = 84) were selected. The Personality Inventory (PI), Beck Depression Inventory (BDI), Prenatal Attachment Inventory (PAI), and Fear of COVID (FCV-19S) were used for data collection. Agreeableness was significantly negatively correlated with fear of COVID-19 (r = -0.33, = 0.002) and positively correlated with prenatal attachment (r = 0.28, = 0.008). Conscientiousness was negatively correlated with prenatal attachment (r = 0.34, = 0.001). Depression was positively correlated with fear of COVID-19 (r = 0.27, = 0.013). Linear regressions showed that agreeableness negatively predicted fear of COVID-19 (β = -0.34, = 0.002) and positively predicted prenatal attachment (β = 0.27, = 0.008). Conscientiousness negatively influenced prenatal attachment (β = -0.35, = 0.001). This study explores personality traits in high-risk pregnancies, a variable underexplored in this clinical population. High-risk pregnancies may lead to adverse outcomes for both mother and child.