Inzoli Alessandra, Barba Marta, Costa Clarissa, Carazita Valeria, Cola Alice, Fantauzzi Martina, Passoni Paolo, Polizzi Serena, Frigerio Matteo
Department of Medicine and Surgery, University of Milan-Bicocca, 20126 Milano, Italy.
Department of Gynecology, Fondazione IRCCS San Gerardo Dei Tintori, University of Milano Bicocca, Via Pergolesi 33, 20900 Monza, Italy.
Healthcare (Basel). 2024 Nov 29;12(23):2403. doi: 10.3390/healthcare12232403.
Chronic pelvic pain is a debilitating condition affecting quality of life. Endometriosis is one of the leading causes of CPP, but recent studies highlighted the role of interstitial cystitis/bladder pain syndrome (IC/PBS) in causing CPP. Only some studies addressed the coexistence of these two conditions, which seems more frequent than what is supposed, leading to diagnostic delays and unnecessary surgeries. This systematic review aimed to evaluate the estimate of the prevalence of the comorbidity of endometriosis and IC/PBS.
We performed a systematic review of the literature indexed on PubMed, Scopus, ISI Web of Science, and Cochrane using a combination of keywords and text words represented by "painful bladder syndrome", "endometriosis", "interstitial cystitis", and "bladder pain syndrome". We performed a meta-analysis of the results.
The meta-analysis shows that the coexistence of endometriosis and IC/PBS in women with CPP ranged from 15.5% to 78.3%, which is higher than the prevalence of IC/PBS in the general population.
Prevalence data about the coexistence of endometriosis and IC/PBS are highly heterogeneous, probably due to the paucity of available data. However, in cases of endometriosis unresponsive to treatment, other reasons for CPP (such as IC/PBS) need to be ruled out.
慢性盆腔疼痛是一种影响生活质量的使人衰弱的病症。子宫内膜异位症是慢性盆腔疼痛的主要原因之一，但最近的研究强调了间质性膀胱炎/膀胱疼痛综合征（IC/PBS）在引起慢性盆腔疼痛中的作用。只有一些研究探讨了这两种病症的共存情况，其似乎比预期更为常见，导致诊断延迟和不必要的手术。本系统评价旨在评估子宫内膜异位症与IC/PBS合并症患病率的估计值。
我们使用“疼痛性膀胱综合征”“子宫内膜异位症”“间质性膀胱炎”和“膀胱疼痛综合征”所代表的关键词和文本词组合，对PubMed、Scopus、ISI科学网和Cochrane上索引的文献进行了系统评价。我们对结果进行了荟萃分析。
荟萃分析表明，慢性盆腔疼痛女性中子宫内膜异位症与IC/PBS共存的比例在15.5%至78.3%之间，高于一般人群中IC/PBS的患病率。
关于子宫内膜异位症与IC/PBS共存的患病率数据高度异质，可能是由于可用数据匮乏。然而，在子宫内膜异位症治疗无效的情况下，需要排除慢性盆腔疼痛的其他原因（如IC/PBS）。
