• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用磷掺杂碳涂层作为改善类金刚石碳生物性能的一种潜在方法。

The Doping of a Carbon Coating with Phosphorus as a Potential Way of Improving the Biological Properties of Diamond-like Carbon.

作者信息

Jastrzębski Krzysztof, Grabarczyk Jacek, Niedzielski Piotr, Jędrzejczak Anna, Sobczyk-Guzenda Anna, Szymański Witold, Kamińska Marta, Skibska Beata

机构信息

Institute of Materials Science and Engineering, Lodz University of Technology, Stefanowskiego 1/15, 90-537 Lodz, Poland.

Department of Applied Pharmacy, Faculty of Pharmacy, Medical University of Lodz, Jana Muszyńskiego 1, 90-001 Lodz, Poland.

出版信息

Materials (Basel). 2024 Nov 29;17(23):5859. doi: 10.3390/ma17235859.

DOI:10.3390/ma17235859
PMID:39685292
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11642205/
Abstract

The potential of diamond-like carbon coatings in medicine can be increased by doping them with various elements. Such modifications especially affect the biological properties of the synthetized films. In the following research, phosphorus was introduced into the carbon matrix by means of the chemical vapor deposition technique and using an organic precursor. With the addition of about 1.6 and 4.3 at% of dopant, not only was the surface roughness increased, but significant changes in both the mechanical and biological properties were also observed. The presence of phosphorus reduced the hardness of DLC coatings but still improved this parameter in comparison to the substrate material-AISI316LVM. A biological examination revealed the bacteriostatic potential of doped coatings regardless of their chemical composition. Increasing the amount of phosphorus improved the proliferation of osteoblasts ( cell), but the opposite effect was achieved for the endothelial cell line ( Another important aspect is the reduction in platelet activation, especially for low amounts of dopant.

摘要

通过用各种元素对类金刚石碳涂层进行掺杂，可以提高其在医学领域的潜力。这种改性尤其会影响合成薄膜的生物学特性。在接下来的研究中，通过化学气相沉积技术并使用有机前驱体将磷引入碳基体中。添加约1.6原子百分比和4.3原子百分比的掺杂剂后，不仅表面粗糙度增加，而且在机械性能和生物学性能方面也观察到了显著变化。磷的存在降低了类金刚石碳涂层的硬度，但与基底材料AISI316LVM相比，该参数仍有所改善。生物学检查表明，无论掺杂涂层的化学成分如何，其都具有抑菌潜力。增加磷的含量可促进成骨细胞（细胞）的增殖，但对内皮细胞系则产生相反的效果。另一个重要方面是血小板活化的减少，尤其是对于少量掺杂剂而言。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/81df453590dc/materials-17-05859-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/4ca2f2876e39/materials-17-05859-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/b376993ae65a/materials-17-05859-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/787116e41bff/materials-17-05859-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/25226f171138/materials-17-05859-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/3ab6cf8c29d5/materials-17-05859-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/e9b378a5e942/materials-17-05859-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/39fa9e1830da/materials-17-05859-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/e293016d8637/materials-17-05859-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/fda8eee99ae7/materials-17-05859-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/d5bc560b99ec/materials-17-05859-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/eb6be76fe3a3/materials-17-05859-g011a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/17827605c750/materials-17-05859-g012a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/8f11c29d99a6/materials-17-05859-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/6b6741c78492/materials-17-05859-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/81df453590dc/materials-17-05859-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/4ca2f2876e39/materials-17-05859-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/b376993ae65a/materials-17-05859-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/787116e41bff/materials-17-05859-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/25226f171138/materials-17-05859-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/3ab6cf8c29d5/materials-17-05859-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/e9b378a5e942/materials-17-05859-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/39fa9e1830da/materials-17-05859-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/e293016d8637/materials-17-05859-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/fda8eee99ae7/materials-17-05859-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/d5bc560b99ec/materials-17-05859-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/eb6be76fe3a3/materials-17-05859-g011a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/17827605c750/materials-17-05859-g012a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/8f11c29d99a6/materials-17-05859-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/6b6741c78492/materials-17-05859-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a183/11642205/81df453590dc/materials-17-05859-g015.jpg

相似文献

1
The Doping of a Carbon Coating with Phosphorus as a Potential Way of Improving the Biological Properties of Diamond-like Carbon.用磷掺杂碳涂层作为改善类金刚石碳生物性能的一种潜在方法。
Materials (Basel). 2024 Nov 29;17(23):5859. doi: 10.3390/ma17235859.
2
Surface characterization and biological evaluation of silver-incorporated DLC coatings fabricated by hybrid RF PACVD/MS method.采用混合射频 PACVD/MS 方法制备的掺银 DLC 涂层的表面特性及生物学评价。
Mater Sci Eng C Mater Biol Appl. 2016 Jun;63:462-74. doi: 10.1016/j.msec.2016.03.013. Epub 2016 Mar 3.
3
SiCNO Coatings Enhance Endothelialization and Bactericidal activity and Reduce Blood Cell Activation.碳化硅氮氧化物涂层可增强内皮化和杀菌活性，并减少血细胞活化。
ACS Biomater Sci Eng. 2020 Oct 12;6(10):5571-5587. doi: 10.1021/acsbiomaterials.0c00472. Epub 2020 Sep 21.
4
Induced Biological Response in Contact with Ag-and Cu-Doped Carbon Coatings for Potential Orthopedic Applications.与银和铜掺杂碳涂层接触时的诱导生物反应在潜在骨科应用中的研究
Materials (Basel). 2021 Apr 9;14(8):1861. doi: 10.3390/ma14081861.
5
Multi-functional bioactive silver- and copper-doped diamond-like carbon coatings for medical implants.用于医疗植入物的多功能生物活性银和铜掺杂类金刚石涂层。
Acta Biomater. 2023 Sep 1;167:54-68. doi: 10.1016/j.actbio.2023.06.037. Epub 2023 Jun 29.
6
Adhesion and differentiation of Saos-2 osteoblast-like cells on chromium-doped diamond-like carbon coatings.Saos-2成骨样细胞在掺铬类金刚石碳涂层上的黏附与分化
J Mater Sci Mater Med. 2017 Jan;28(1):17. doi: 10.1007/s10856-016-5830-2. Epub 2016 Dec 20.
7
Deposition of boron doped DLC films on TiNb and characterization of their mechanical properties and blood compatibility.硼掺杂类金刚石薄膜在TiNb上的沉积及其力学性能和血液相容性表征。
Sci Technol Adv Mater. 2017 Jan 16;18(1):76-87. doi: 10.1080/14686996.2016.1262196. eCollection 2017.
8
Fluorine doping into diamond-like carbon coatings inhibits protein adsorption and platelet activation.向类金刚石碳涂层中掺杂氟可抑制蛋白质吸附和血小板活化。
J Biomed Mater Res A. 2007 Dec 15;83(4):1192-1199. doi: 10.1002/jbm.a.31340.
9
Preparation and Characterization of Diamond-like Carbon Coatings for Biomedical Applications-A Review.用于生物医学应用的类金刚石碳涂层的制备与表征——综述
Materials (Basel). 2023 Apr 27;16(9):3420. doi: 10.3390/ma16093420.
10
Electrochemically assisted deposition of hydroxyapatite on Ti6Al4V substrates covered by CVD diamond films - Coating characterization and first cell biological results.在化学气相沉积（CVD）金刚石薄膜覆盖的Ti6Al4V基底上进行羟基磷灰石的电化学辅助沉积——涂层表征及首次细胞生物学结果
Mater Sci Eng C Mater Biol Appl. 2016 Feb;59:624-635. doi: 10.1016/j.msec.2015.10.063. Epub 2015 Oct 22.

本文引用的文献

1
Poly(l-Histidine)-Mediated On-Demand Therapeutic Delivery of Roughened Ceria Nanocages for Treatment of Chemical Eye Injury.聚（组氨酸）介导的粗糙氧化铈纳米笼按需治疗化学性眼损伤。
Adv Sci (Weinh). 2023 Sep;10(26):e2302174. doi: 10.1002/advs.202302174. Epub 2023 Jul 10.
2
Multi-functional bioactive silver- and copper-doped diamond-like carbon coatings for medical implants.用于医疗植入物的多功能生物活性银和铜掺杂类金刚石涂层。
Acta Biomater. 2023 Sep 1;167:54-68. doi: 10.1016/j.actbio.2023.06.037. Epub 2023 Jun 29.
3
Phosphate promotes osteogenic differentiation through non-canonical Wnt signaling pathway in human mesenchymal stem cells.
磷酸盐通过非经典 Wnt 信号通路促进人骨髓间充质干细胞的成骨分化。
Bone. 2022 Nov;164:116525. doi: 10.1016/j.bone.2022.116525. Epub 2022 Aug 18.
4
Size-dependent osteogenesis of black phosphorus in nanocomposite hydrogel scaffolds.尺寸依赖的黑磷在纳米复合水凝胶支架中的成骨作用。
J Biomed Mater Res A. 2022 Aug;110(8):1488-1498. doi: 10.1002/jbm.a.37382. Epub 2022 Mar 23.
5
P-Doped Carbon Quantum Dots with Antibacterial Activity.具有抗菌活性的P掺杂碳量子点
Micromachines (Basel). 2021 Sep 16;12(9):1116. doi: 10.3390/mi12091116.
6
Induced Biological Response in Contact with Ag-and Cu-Doped Carbon Coatings for Potential Orthopedic Applications.与银和铜掺杂碳涂层接触时的诱导生物反应在潜在骨科应用中的研究
Materials (Basel). 2021 Apr 9;14(8):1861. doi: 10.3390/ma14081861.
7
The changing landscape of atherosclerosis.动脉粥样硬化的变化格局。
Nature. 2021 Apr;592(7855):524-533. doi: 10.1038/s41586-021-03392-8. Epub 2021 Apr 21.
8
Antibacterial, angiogenic, and osteogenic activities of Ca, P, Co, F, and Sr compound doped titania coatings with different Sr content.掺不同 Sr 量的 Ca、P、Co、F 和 Sr 化合物的 TiO2 涂层的抗菌、血管生成和成骨活性。
Sci Rep. 2019 Oct 2;9(1):14203. doi: 10.1038/s41598-019-50496-3.
9
Engineering natural matrices with black phosphorus nanosheets to generate multi-functional therapeutic nanocomposite hydrogels.利用黑磷纳米片工程化天然基质，生成多功能治疗性纳米复合水凝胶。
Biomater Sci. 2019 Oct 1;7(10):4046-4059. doi: 10.1039/c9bm01072f. Epub 2019 Aug 22.
10
Exfoliated Black Phosphorus Promotes in Vitro Bone Regeneration and Suppresses Osteosarcoma Progression through Cancer-Related Inflammation Inhibition.剥离型黑磷通过抑制癌相关炎症促进体外骨再生和抑制骨肉瘤进展。
ACS Appl Mater Interfaces. 2019 Mar 6;11(9):9333-9342. doi: 10.1021/acsami.8b21592. Epub 2019 Feb 22.