Khodanovich Marina Y, Svetlik Mikhail V, Naumova Anna V, Usova Anna V, Pashkevich Valentina Y, Moshkina Marina V, Shadrina Maria M, Kamaeva Daria A, Obukhovskaya Victoria B, Kataeva Nadezhda G, Levina Anastasia Y, Tumentceva Yana A, Yarnykh Vasily L
Laboratory of Neurobiology, Research Institute of Biology and Biophysics, Tomsk State University, 36 Lenina Ave., Tomsk 634050, Russia.
Department of Radiology, School of Medicine, South Lake Union Campus, University of Washington, 850 Republican St., Seattle, WA 98109, USA.
J Clin Med. 2024 Nov 22;13(23):7065. doi: 10.3390/jcm13237065.
The fundamental question of normal brain myelination in human is still poorly understood. : Age-dependent global, regional, and interhemispheric sex-related differences in brain myelination of 42 (19 men, 23 women) healthy adults (19-67 years) were explored using the MRI method of fast macromolecular fraction (MPF) mapping. : Higher brain myelination in males compared to females was found in global white matter (WM), most WM tracts, juxtacortical WM regions, and putamen. The largest differences between men and women, exceeding 4%, were observed bilaterally in the frontal juxtacortical WM; angular, inferior occipital, and cuneus WM; external capsule; and inferior and superior fronto-orbital fasciculi. The majority of hemispheric differences in MPF were common to men and women. Sex-specific interhemispheric differences were found in juxtacortical WM; men more often had left-sided asymmetry, while women had right-sided asymmetry. Most regions of deep gray matter (GM), juxtacortical WM, and WM tracts (except for projection pathways) showed a later peak age of myelination in women compared to men, with a difference of 3.5 years on average. Body mass index (BMI) was associated with higher MPF and later peak age of myelination independent of age and sex. : MPF mapping showed high sensitivity to assess sex-related differences in normal brain myelination, providing the basis for using this method in clinics.
人类正常脑髓鞘形成的基本问题仍未得到充分理解。使用快速大分子分数（MPF）映射的MRI方法，对42名（19名男性，23名女性）19 - 67岁健康成年人的脑髓鞘形成随年龄变化的整体、区域和半球间性别差异进行了研究。研究发现，男性在整体白质（WM）、大多数WM束、皮质下WM区域和壳核中的脑髓鞘形成高于女性。男性和女性之间最大的差异超过4%，在双侧额叶皮质下WM、角回、枕下回和楔叶WM、外囊以及额眶上束和额眶下束中均有观察到。MPF的大多数半球间差异在男性和女性中是常见的。在皮质下WM中发现了特定性别的半球间差异；男性更常出现左侧不对称，而女性则出现右侧不对称。与男性相比，大多数深部灰质（GM）、皮质下WM和WM束区域（投射通路除外）的髓鞘形成峰值年龄较晚，平均相差3.5岁。体重指数（BMI）与较高的MPF和较晚的髓鞘形成峰值年龄相关，且不受年龄和性别的影响。MPF映射显示出在评估正常脑髓鞘形成的性别差异方面具有很高的敏感性，为该方法在临床上的应用提供了依据。
