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暴露于钛固定物-Ti6Al4V后上颌骨和下颌骨骨膜的细胞因子、趋化因子及生长因子模式

The Pattern of Cytokines, Chemokines, and Growth Factors of the Maxillary and Mandibular Periosteum After Exposure to Titanium Fixations-Ti6Al4V.

作者信息

Antonowicz Bożena, Maciejczyk Mateusz, Borys Jan, Łukaszuk Kamila, Zięba Sara, Gołaś Edyta, Żendzian-Piotrowska Małgorzata, Zalewska Anna

机构信息

Department of Dental Surgery, Medical University in Bialystok, 15-089 Białystok, Poland.

Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, 15-089 Białystok, Poland.

出版信息

J Clin Med. 2024 Nov 22;13(23):7064. doi: 10.3390/jcm13237064.

DOI:10.3390/jcm13237064
PMID:39685524
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11642897/
Abstract

Titanium miniplates and screws are commonly used in the surgical management of dentofacial deformities. Despite the opinion of the biocompatibility of these bone fixations, some patients experience symptoms of chronic inflammation around titanium implants even many years after their application. The aim of this study was to examine the levels of cytokines, chemokines, and growth factors released from the maxilla and mandible periosteum surrounding titanium fixations 11 months after the implantation procedure. From the study group (n = 20) consisting of patients with maxillofacial defects who underwent bimaxillary osteotomy, fragments of the periosteum of the maxilla and mandible adjacent to the titanium miniplates and screws were taken during routine bone fixation removal procedures. From the control group subjects (n = 20), fragments of healthy maxillary and mandibular periosteum were taken prior to surgical treatment of dentofacial deformities. The examination of cytokines, chemokines, and growth factors levels released from the periosteum of jaws was performed using the Bio-Plex Pro Human Cytokine Screening Panel (48-Plex). The study group was characterized by a significant increase in the concentration of most of the tested-for proinflammatory cytokines/chemokines/growth factors compared to the control group, with greater amounts of inflammatory factors released from the periosteum covering the titanium implants in the mandible than from the periosteal cells surrounding the titanium implants in the maxilla. Prolonged exposure to titanium miniplates and screws leads to a disturbance of immune homeostasis in the periosteal cells of the maxilla and mandible. The data obtained indicate the need to remove fixations after the bone fragments have healed.

摘要

钛微型钢板和螺钉常用于牙颌面畸形的外科治疗。尽管人们认为这些骨固定装置具有生物相容性，但一些患者即使在植入多年后仍会出现钛植入物周围慢性炎症的症状。本研究的目的是检测植入手术后11个月钛固定装置周围上颌骨和下颌骨骨膜释放的细胞因子、趋化因子和生长因子水平。在由接受双颌截骨术的颌面部缺损患者组成的研究组（n = 20）中，在常规骨固定拆除手术过程中采集与钛微型钢板和螺钉相邻的上颌骨和下颌骨骨膜碎片。在对照组受试者（n = 20）中，在牙颌面畸形手术治疗前采集健康的上颌骨和下颌骨骨膜碎片。使用Bio-Plex Pro人细胞因子筛选板（48孔板）检测颌骨骨膜释放的细胞因子、趋化因子和生长因子水平。与对照组相比，研究组的大多数检测促炎细胞因子/趋化因子/生长因子浓度显著升高，下颌骨覆盖钛植入物的骨膜释放的炎症因子比上颌骨钛植入物周围的骨膜细胞释放的炎症因子更多。长期暴露于钛微型钢板和螺钉会导致上颌骨和下颌骨骨膜细胞免疫稳态紊乱。获得的数据表明，在骨碎片愈合后需要拆除固定装置。

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