Corrêa Monica Grazieli, Pimentel Suzana Peres, Ribeiro Fernanda Vieira, Cirano Fabiano Ribeiro, Casati Marcio Zaffalon
Universidade Paulista - UNIP, School of Dentistry, Dental Research Division, São Paulo, SP, Brazil.
Braz Oral Res. 2019 Sep 30;33(suppl 1):e066. doi: 10.1590/1807-3107bor-2019.vol33.0066. eCollection 2019.
Considering the absence of predictable and effective therapeutic interventions for the treatment of peri-implantitis, scientific evidence concerning the host response profile around dental implants could be important for providing in the future a wider preventive and/or therapeutic window for this peri-implant lesion, indicating biomarkers that provide quantifiable measure of response to peri-implant therapy. Moreover, a better knowledge of pattern of host osteo-immunoinflammatory modulation in the presence of peri-implantitis could either benefit the early diagnostic of the disease or to cooperate to prognostic information related to the status of the peri-implant breakdown. Finally, new evidences concerning the host profile of modulators of inflammation and of osseous tissue metabolism around dental implants could explain the individual susceptibility for developing peri-implant lesions, identifying individuals or sites with increased risk for peri-implantitis. The focus of this chapter was, based on a systematically searched and critically reviewed literature, summarizing the existing knowledge in the scientific research concerning the host osteo-immunoinflammatory response to the microbiological challenge related to periimplantitis.
鉴于目前缺乏可预测且有效的治疗种植体周围炎的干预措施，有关牙种植体周围宿主反应特征的科学证据对于未来为这种种植体周围病变提供更广泛的预防和/或治疗窗口可能具有重要意义，这意味着生物标志物能够提供对种植体周围治疗反应的可量化测量。此外，更好地了解种植体周围炎存在时宿主骨免疫炎症调节模式，既有助于疾病的早期诊断，也有助于提供与种植体周围组织破坏状态相关的预后信息。最后，关于牙种植体周围炎症调节因子和骨组织代谢宿主特征的新证据，可以解释个体发生种植体周围病变的易感性，识别种植体周围炎风险增加的个体或部位。本章的重点是，基于系统检索和严格审查的文献，总结科学研究中关于宿主对与种植体周围炎相关的微生物挑战的骨免疫炎症反应的现有知识。
