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移植评估评分量表(TERS)对活体肾移植受者心理社会结局的预测能力:一项为期两年的前瞻性研究。

The Predictive Power of the Transplant Evaluation Rating Scale (TERS) for Psychosocial Outcomes in Living-Donor Kidney Transplant Recipients: A Two-Year Prospective Study.

作者信息

Richter Ernst Peter, Schlegel Betty, Berth Hendrik

机构信息

Research Group Applied Medical Psychology and Medical Sociology, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, 01307 Dresden, Germany.

出版信息

J Clin Med. 2024 Nov 22;13(23):7076. doi: 10.3390/jcm13237076.

Abstract

The Transplant Evaluation Rating Scale (TERS) assesses the psychosocial risk of transplant candidates; however, its predictive value for outcomes in living-donor kidney transplant (LDKT) recipients remains unclear. This study evaluated the predictive power of the TERS for psychosocial outcomes in LDKT recipients over two years post-transplant. In this prospective single-center cohort study, 107 LDKT recipients completed assessments pre-transplant (T0), 6 months post-transplant (T1), and 24 months post-transplant (T2). The outcomes measured were mental distress, physical complaints, and perceived social support. Linear mixed-effects models were used to examine the relationship between the pre-transplant TERS scores and outcomes over time. Higher TERS scores predicted increased physical complaints ( < 0.001) and lower perceived social support ( = 0.035) at all time points. Additionally, higher TERS scores were associated with greater mental distress between T0 and T2 ( < 0.001). A hierarchical partitioning revealed that the TERS accounted for 11.9% of the variance in mental distress, 14.6% of that in physical complaints, and 6.0% of that in perceived social support. The pre-transplant psychosocial risk, as measured by the TERS, significantly predicted the psychosocial outcomes in the LDKT recipients over two years, with small-to-medium effect sizes. The TERS may serve as a valuable tool for identifying patients who could benefit from targeted psychosocial interventions to improve their long-term outcomes.

摘要

移植评估评分量表(TERS)用于评估移植候选者的心理社会风险;然而,其对活体供肾移植(LDKT)受者结局的预测价值仍不明确。本研究评估了TERS对LDKT受者移植后两年心理社会结局的预测能力。在这项前瞻性单中心队列研究中,107名LDKT受者在移植前(T0)、移植后6个月(T1)和移植后24个月(T2)完成了评估。测量的结局包括精神困扰、身体不适和感知到的社会支持。使用线性混合效应模型来检验移植前TERS评分与不同时间点结局之间的关系。较高的TERS评分在所有时间点均预测身体不适增加(<0.001)和感知到的社会支持降低(=0.035)。此外,较高的TERS评分与T0至T2期间更大的精神困扰相关(<0.001)。层次划分显示,TERS分别解释了精神困扰方差的11.9%、身体不适方差的14.6%和感知到的社会支持方差的6.0%。TERS所测量的移植前心理社会风险显著预测了LDKT受者两年内的心理社会结局,效应大小为小到中等。TERS可能是一种有价值的工具,可用于识别那些可能从有针对性的心理社会干预中受益以改善其长期结局的患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d756/11642563/d058f97381c5/jcm-13-07076-g001.jpg

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