Fiorentino Mariafrancesca, Mikus Elisa, Nerla Roberto, Sangiorgi Diego, Ruggiero Andrea, Tripodi Alberto, Castriota Fausto, Savini Carlo
Cardiovascular Department, Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Italy.
Department of Experimental Diagnostic and Surgical Medicine (DIMEC), University of Bologna, 40126 Bologna, Italy.
J Clin Med. 2024 Nov 26;13(23):7180. doi: 10.3390/jcm13237180.
: Coexisting coronary artery disease and critical carotid stenosis present challenges in revascularization, particularly in urgent cases requiring surgery. Combining carotid artery stenting (CAS) with coronary artery bypass grafting (CABG) has gained popularity. : This study analyzed 36 patients who underwent simultaneous CAS and CABG from 2014 to 2024. CAS was performed first, with the patient awake for real-time neurocognitive assessment. A clopidogrel loading dose was administered three hours post-surgery. From postoperative day 1, dual antiplatelet therapy was initiated. : The median age was 72 years (64-77) and 22.2% were females. The median EuroSCORE II was 2.80 (2.06-3.58). Nine patients (25%) underwent associated procedures. The median cardiopulmonary bypass and cross-clamp times were 66 (54-89) and 51 (41-72) minutes. We observed no in-hospital mortality and no postoperative stroke. The median postoperative bleeding in 24 h was 500 mL and only one (2.8%) patient needed resternotomy for bleeding. The median ventilation time was 9 h (6-12). The median intensive care unit and postoperative length of stay were 2 (2-4) days and 8 (7-11) days, respectively. The median follow-up time was 6 years. Survival at 1, 5, and 10 years was 93.7%, 81.5%, and 60.2%, respectively, while freedom from PTCA/PCI at 1, 5, and 10 years was 100%, 96.7%, and 87.5%, respectively. : Simultaneous CAS and CABG is a safe and effective procedure with low in-hospital mortality and morbidity. Our protocol carries a low risk of perioperative stroke. Antiplatelet therapy administration on the day of surgery does not increase the risk of postoperative bleeding.
冠状动脉疾病与严重颈动脉狭窄并存给血运重建带来了挑战,尤其是在需要手术的紧急情况下。将颈动脉支架置入术(CAS)与冠状动脉旁路移植术(CABG)相结合已越来越普遍。本研究分析了2014年至2024年期间同时接受CAS和CABG的36例患者。先进行CAS,患者在清醒状态下接受实时神经认知评估。术后三小时给予氯吡格雷负荷剂量。从术后第1天开始启动双联抗血小板治疗。中位年龄为72岁(64 - 77岁),女性占22.2%。中位欧洲心脏手术风险评估系统(EuroSCORE)II评分为2.80(2.06 - 3.58)。9例患者(25%)接受了相关手术。中位体外循环和主动脉阻断时间分别为66分钟(54 - 89分钟)和51分钟(41 - 72分钟)。我们观察到无院内死亡病例,也无术后卒中发生。术后24小时的中位出血量为500毫升,只有1例(2.8%)患者因出血需要再次开胸手术。中位通气时间为9小时(6 - 12小时)。中位重症监护病房停留时间和术后住院时间分别为2天(2 - 4天)和8天(7 - 11天)。中位随访时间为6年。1年、5年和10年的生存率分别为93.7%、81.5%和60.2%,而1年、5年和10年无经皮冠状动脉腔内血管成形术(PTCA)/冠状动脉介入治疗(PCI)的比例分别为100%、96.7%和87.5%。同时进行CAS和CABG是一种安全有效的手术,院内死亡率和发病率较低。我们的方案围手术期卒中风险较低。手术当天给予抗血小板治疗不会增加术后出血风险。