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急性心血管疾病患者严重贫血的输血需求——康斯坦察县心脏病学部门的单中心回顾性研究

Transfusion Requirements for Severe Anemia in Acute Cardiovascular Patients-A Single Center Retrospective Study in Constanta County Cardiology Department.

作者信息

Ali Sevigean, Badea Iulia Andreea, Botnarciuc Mihaela, Daba Lavinia Carmen, Alexandru Andreea, Tuta Liliana-Ana, Parepa Irinel Raluca, Stanigut Alina Mihaela, Ionescu Mihaela

机构信息

Preclinical Disciplines Department, Faculty of Medicine, Campus B, Ovidius University of Constanta, Aleea Universitatii nr. 1, 900470 Constanta, Romania.

Blood Transfusions Unit, Emergency Clinical County Hospital Constanta, Bdul Tomis nr. 145, 900591 Constanta, Romania.

出版信息

J Clin Med. 2024 Nov 28;13(23):7235. doi: 10.3390/jcm13237235.

Abstract

Anemia is common in hospitalized cardiac patients and affects prognosis and cardiovascular mortality in patients with acute decompensated heart failure. to investigate the impact of anemia severity, blood transfusion practices, and the evolution and outcome in patients with acute cardiovascular events. We performed a retrospective analysis of the patients hospitalized in the Cardiology Department of Constanta County Hospital who required blood derivatives transfusions, between 1 January 2021 and 31 December 2021. Out of the total 270 patients, 170 received a single unit of resuspended erythrocyte concentrate within the same month, while 100 required multiple transfusions, receiving between 2 and 5 units during a single hospitalization, to correct anemia. Before transfusions, the mean hemoglobin (Hb) level was 7.60 g/dL, with values ranging from 6.50 g/dL to 9.10 g/dL. Men show a higher prevalence (64%) than women (36%), likely due to gender differences in susceptibility to heart conditions. Patients with associated acute or chronic renal failure consistently experience higher in-hospital mortality in all left ventricular ejection fraction (LVEF) subgroups. Anemia in heart failure patients is linked to worsening symptoms, decreased kidney function, and higher hospitalization and mortality rates. The findings aim to inform and optimize clinical decision making, particularly regarding transfusion strategies and risk management in this high-risk population.

摘要

贫血在住院心脏病患者中很常见,并且会影响急性失代偿性心力衰竭患者的预后和心血管死亡率。旨在研究贫血严重程度、输血方式以及急性心血管事件患者的病情演变和结局的影响。我们对2021年1月1日至2021年12月31日期间在康斯坦察县医院心内科住院且需要输注血液制品的患者进行了回顾性分析。在总共270例患者中,170例在同一个月内接受了单单位悬浮红细胞浓缩液,而100例需要多次输血,在单次住院期间接受2至5个单位以纠正贫血。输血前,平均血红蛋白(Hb)水平为7.60 g/dL,范围为6.50 g/dL至9.10 g/dL。男性的患病率(64%)高于女性(36%),这可能是由于对心脏疾病易感性的性别差异。伴有急性或慢性肾衰竭的患者在所有左心室射血分数(LVEF)亚组中住院死亡率持续较高。心力衰竭患者的贫血与症状恶化、肾功能下降以及更高的住院率和死亡率相关。这些研究结果旨在为临床决策提供信息并进行优化,特别是关于这一高危人群的输血策略和风险管理。

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