Wang Xuejie, Wang Ziqiu, Du Wen, Ma Xiaobo, Ma Jun, Chen Zijin, Gao Chenni, Chen Xiaonong
Department of Nephrology, Ruijin Hospital Lu Wan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
J Clin Med. 2024 Dec 5;13(23):7423. doi: 10.3390/jcm13237423.
The associations between triglyceride glucose (TyG), triglyceride glucose-body mass index (TyG-BMI), and non-alcoholic fatty liver disease (NAFLD) in high-altitude regions remain unclear. This is a cross-sectional, population-based study comprising 1384 adults living in Jianchuan county, China, which has an average altitude of over 2200 m. Logistic regressions were used to examine the associations between TyG, TyG-BMI, and NAFLD. Receiver operating characteristic (ROC) curves were utilized to compare the predictive ability of TyG, TyG-BMI, hepatic steatosis index (HSI), and triglyceride glucose-alanine aminotransferase (TyG-ALT). In total, 307 (35.7%) male and 81 (15.4%) female participants were diagnosed with NAFLD. Individuals with NAFLD had higher BMI, blood pressure, and TyG indices. The adjusted odds ratios (95% confidence intervals) for the highest quartile of TyG and TyG-BMI were 16.04 (8.51-30.25) and 48.55 (25.12-93.81), respectively. The areas under the ROC curve were 0.811 (95% CI: 0.787-0.836) for TyG, 0.883 (95% CI: 0.864-0.902) for TyG-BMI, 0.839 (95% CI: 0.817-0.863) for HSI, and 0.831 (95% CI: 0.801-0.855) for TyG-ALT. Tyg-BMI had the highest sensitivity (0.832) and specificity (0.780) compared to the other indices. Both TyG and TyG-BMI were associated with higher NAFLD risk in people living in high-altitude regions, while TyG-BMI had greater predictive capabilities.
在高海拔地区，甘油三酯葡萄糖（TyG）、甘油三酯葡萄糖-体重指数（TyG-BMI）与非酒精性脂肪性肝病（NAFLD）之间的关联仍不明确。这是一项基于人群的横断面研究，研究对象为居住在中国剑川县的1384名成年人，该县平均海拔超过2200米。采用逻辑回归分析来研究TyG、TyG-BMI与NAFLD之间的关联。利用受试者工作特征（ROC）曲线比较TyG、TyG-BMI、肝脏脂肪变性指数（HSI）和甘油三酯葡萄糖-丙氨酸氨基转移酶（TyG-ALT）的预测能力。共有307名（35.7%）男性和81名（15.4%）女性参与者被诊断为NAFLD。患有NAFLD的个体具有更高的体重指数、血压和TyG指数。TyG和TyG-BMI最高四分位数的校正比值比（95%置信区间）分别为16.04（8.51-30.25）和48.55（25.12-93.81）。TyG的ROC曲线下面积为0.811（95%CI：0.787-0.836），TyG-BMI为0.883（95%CI：0.864-0.902），HSI为0.839（95%CI：0.817-0.863），TyG-ALT为0.831（95%CI：0.801-0.855）。与其他指标相比，TyG-BMI具有最高的敏感性（0.832）和特异性（0.780）。TyG和TyG-BMI均与高海拔地区人群患NAFLD的较高风险相关，而TyG-BMI具有更强的预测能力。
