2012 年至 2021 年代谢功能障碍相关脂肪性肝病（MAFLD）研究的新兴趋势和热点：文献计量分析。

BACKGROUND: Metabolic dysfunction-associated fatty liver disease (MAFLD) has become the most common chronic liver disease. MAFLD is a major risk factor for end-stage liver disease including cirrhosis and primary liver cancer. The pathogenesis of MAFLD is complex and has not yet been clarified. To the best of our knowledge, few studies have conducted quantitative bibliometric analysis to evaluate published MAFLD research. In this study, we conducted a comprehensive analysis of MAFLD publications over the past decade to summarize the current research hotspots and predict future research directions in this field. METHODS: Articles into MAFLD published from 2012 to 2021 were identified from the Science Citation Index-Expanded of Web of Science Core Collection. CiteSpace software, VOSviewer, the "bibliometrix" R package, and the Online Analysis Platform of Literature Metrology were used to analyze the current publication trends and hotspots. RESULTS: We retrieved 13959 English articles about MAFLD published from 2012 to 2021. Primary sites of publication were dominated by the United States until 2014, when China became the source of most published MAFLD-related research papers. The United States was found to be the most engaged country in international cooperative efforts. Shanghai Jiao Tong University was the most productive institution. Loomba R was the most productive author with 123 articles. The co-cited keyword cluster tag showed ten main clusters: #0 liver fibrosis, #1 hemoglobin, #2 metabolic associated fatty liver disease, #3 egcg, #4 myocardial infarction, #5 heart disease, #6 pnpla3, #7 hepatocellular carcinoma, #8 noninvasive marker, and #9 children. Keyword burst analysis showed that gut microbiota was the highest-intensity research hotspot. CONCLUSION: In the past decade, the number of publications on MAFLD increased dramatically, especially in the last three years. Gut microbiota became an important research direction for etiological and therapeutic investigations into MAFLD. Insulin resistance was also a key factor in studying the development of MAFLD in recent years. Liver fibrosis was an important focus of disease development. This study provides systematic information, helps guide future research, and helps to identify mechanisms and new treatment methods for MAFLD.

背景：代谢相关脂肪性肝病（MAFLD）已成为最常见的慢性肝病。MAFLD 是包括肝硬化和原发性肝癌在内的终末期肝病的主要危险因素。MAFLD 的发病机制复杂，尚未阐明。据我们所知，很少有研究对 MAFLD 研究进行定量文献计量分析。在本研究中，我们对过去十年中 MAFLD 出版物进行了全面分析，以总结该领域当前的研究热点，并预测未来的研究方向。

方法：从 Web of Science 核心合集的科学引文索引扩展版中确定了 2012 年至 2021 年发表的 MAFLD 文章。使用 CiteSpace 软件、VOSviewer、“bibliometrix”R 包和文献计量在线分析平台分析当前的出版趋势和热点。

结果：我们检索到 2012 年至 2021 年发表的 13959 篇关于 MAFLD 的英文文章。主要出版地点一直由美国主导，直到 2014 年，中国成为发表 MAFLD 相关研究论文的主要来源地。美国被认为是国际合作最活跃的国家。上海交通大学是最有成效的机构。Loomba R 是最有成效的作者，有 123 篇文章。共被引关键词聚类标签显示了十个主要聚类：#0 肝纤维化、#1 血红蛋白、#2 代谢相关脂肪性肝病、#3 egcg、#4 心肌梗死、#5 心脏病、#6 pnpla3、#7 肝细胞癌、#8 非侵入性标志物和#9 儿童。关键词突发分析显示，肠道微生物群是研究强度最高的热点。

结论：在过去十年中，MAFLD 的出版物数量急剧增加，尤其是在过去三年。肠道微生物群成为 MAFLD 病因学和治疗学研究的重要方向。胰岛素抵抗也是近年来研究 MAFLD 发展的关键因素。肝纤维化是疾病发展的一个重要焦点。本研究提供了系统的信息，有助于指导未来的研究，并有助于发现 MAFLD 的发病机制和新的治疗方法。