Chung Jae Sik, An Sanghyun, Moon Hyeun Eui, Kim Yonsu, Chung Tae-Ha
Department of Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju 26426, Republic of Korea.
Department of Medicine, Graduate School, Yonsei University Mirae Campus, Wonju 26493, Republic of Korea.
J Clin Med. 2024 Dec 8;13(23):7467. doi: 10.3390/jcm13237467.
The global prevalence of obesity continues to rise. However, whether obesity affects the degree of intra-abdominal solid organ damage following blunt trauma remains unclear. This study aimed to investigate the correlation between obesity and intra-abdominal solid organ damage. This cross-sectional study was conducted at a regional trauma center in the Republic of Korea from January 2018 to December 2022 and included 582 patients aged 18-98 years with blunt abdominal trauma. Patients were categorized into four groups-underweight, normal weight, overweight, and obesity-based on their body mass index (BMI). Odds ratios (ORs), beta coefficients, and 95% confidence intervals (CIs) for intra-abdominal organ damage were calculated across BMI categories using multiple logistic regression analysis after adjusting for the confounding variables. The obesity group exhibited a significant decrease in the prevalence of liver injury (OR: 0.553, CI: 0.316 to 0.966) and a reduction in liver injury severity (β: -0.214, CI: -0.391 to -0.037) compared with the normal-weight group after adjusting for the confounding factors. However, no significant association was observed between the BMI and injuries to other solid organs, such as the spleen, pancreas, and kidneys. Additionally, the younger obesity group (participants aged < 45 years) exhibited a significant negative association with both liver injury and injury grade. However, the older obesity group (participants aged > 65 years) exhibited a statistically significant association only with the liver injury grade compared with the normal-weight group. Obesity can serve as a predictive factor for the presence and severity of liver damage caused by blunt abdominal trauma.
全球肥胖患病率持续上升。然而，肥胖是否会影响钝性创伤后腹腔内实性器官的损伤程度仍不清楚。本研究旨在探讨肥胖与腹腔内实性器官损伤之间的相关性。这项横断面研究于2018年1月至2022年12月在韩国一家地区创伤中心进行，纳入了582例年龄在18 - 98岁之间的钝性腹部创伤患者。根据体重指数（BMI）将患者分为四组：体重过轻、正常体重、超重和肥胖。在调整混杂变量后，使用多元逻辑回归分析计算不同BMI类别中腹腔内器官损伤的比值比（OR）、β系数和95%置信区间（CI）。在调整混杂因素后，与正常体重组相比，肥胖组肝损伤患病率显著降低（OR：0.553，CI：0.316至0.966），肝损伤严重程度降低（β：-0.214，CI：-0.391至-0.037）。然而，未观察到BMI与脾脏、胰腺和肾脏等其他实性器官损伤之间存在显著关联。此外，较年轻的肥胖组（年龄<45岁的参与者）与肝损伤和损伤分级均呈显著负相关。然而，与正常体重组相比，年龄较大的肥胖组（年龄>65岁的参与者）仅与肝损伤分级存在统计学显著关联。肥胖可作为钝性腹部创伤所致肝损伤存在及严重程度的预测因素。
