Castiglia Stefano Filippo, Sebastianelli Gabriele, Abagnale Chiara, Casillo Francesco, Trabassi Dante, Di Lorenzo Cherubino, Ziccardi Lucia, Parisi Vincenzo, Di Renzo Antonio, De Icco Roberto, Tassorelli Cristina, Serrao Mariano, Coppola Gianluca
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, 04100 Latina, Italy.
Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy.
Sensors (Basel). 2024 Nov 28;24(23):7627. doi: 10.3390/s24237627.
BACKGROUND/HYPOTHESIS: Motion sensitivity symptoms, such as dizziness or unsteadiness, are frequently reported as non-headache symptoms of migraine. Postural imbalance has been observed in subjects with vestibular migraine, chronic migraine, and aura. We aimed to assess the ability of largest Lyapunov's exponent for a short time series (sLLE), which reflects the ability to cope with internal perturbations during gait, to detect differences in local dynamic stability between individuals with migraine without aura (MO) with an episodic pattern between attacks and healthy subjects (HS).
Trunk accelerations of 47 MO and 38 HS were recorded during gait using an inertial measurement unit. The discriminative ability of sLLE was assessed through receiver-operating characteristics curves and cutoff analysis. Partial correlation analysis was conducted between the clinical and gait variables, excluding the effects of gait speed.
MO showed higher sLLE values, and reduced pelvic rotation, pelvic tilt, and stride length values. sLLEML and pelvic rotation showed good ability to discriminate between MO and HS and were correlated with the perceived pain, migraine disability assessment score, and each other.
these findings may provide new insights into the postural balance control mechanism in subjects with MO and introduce the sLLEML as a potential measure of dynamic instability in MO.
背景/假设：运动敏感症状，如头晕或不稳，常被报告为偏头痛的非头痛症状。在前庭性偏头痛、慢性偏头痛和有先兆偏头痛的患者中已观察到姿势失衡。我们旨在评估反映步态中应对内部扰动能力的短时间序列最大Lyapunov指数（sLLE）检测无先兆偏头痛（MO）发作呈发作性模式的个体与健康受试者（HS）之间局部动态稳定性差异的能力。
使用惯性测量单元在步态期间记录47名MO患者和38名HS患者的躯干加速度。通过受试者工作特征曲线和截断分析评估sLLE的判别能力。在排除步态速度影响的情况下，对临床和步态变量进行偏相关分析。
MO患者的sLLE值较高，骨盆旋转、骨盆倾斜和步长值降低。sLLEML和骨盆旋转在区分MO和HS方面表现出良好能力，且与感知疼痛、偏头痛残疾评估评分以及彼此相关。
这些发现可能为MO患者姿势平衡控制机制提供新见解，并引入sLLEML作为MO动态不稳定的潜在测量指标。
