Hongxing Zhang, Jiafeng Peng, Minglei Gao, Danyang Li, Zhu Junchen
The Department of Second Clinical Medical College, Anhui University of Chinese Medicine, Hefei, China.
The Department of Orthopaedics, the Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China.
Medicine (Baltimore). 2024 Dec 13;103(50):e40876. doi: 10.1097/MD.0000000000040876.
The relationship between hyponatremia and osteoporosis is controversial, and it remains unclear if there is a causal link between the two. This study employed a 2-sample Mendelian randomization (MR) analysis to investigate the potential causal relationship between hyponatremia and osteoporosis. The instrumental variables were derived from genome-wide association studies conducted in European populations. These included hyponatremia (n = 465,348) as the exposure factor, with genetic summary data for bone mineral density (BMD) at the forearm (n = 8134), femoral neck (n = 32,735), lumbar spine (n = 28,498), and heel (n = 265,627) as outcomes. The inverse variance weighted method did not identify any causal effect of hyponatremia on BMD. Additionally, other methods, such as MR-Egger, weighted median, simple mode, and weighted mode, also did not show evidence of a causal relationship between hyponatremia and BMD. Pleiotropy and heterogeneity analyses indicated that the MR findings were robust. There is no significant causal relationship between hyponatremia and osteoporosis. The previously observed associations may be due to confounding factors. It is unlikely that hyponatremia is a causal factor for osteoporosis.
低钠血症与骨质疏松症之间的关系存在争议，二者之间是否存在因果联系仍不明确。本研究采用两样本孟德尔随机化（MR）分析来探究低钠血症与骨质疏松症之间的潜在因果关系。工具变量来源于在欧洲人群中进行的全基因组关联研究。这些研究包括将低钠血症（n = 465,348）作为暴露因素，以前臂骨密度（BMD）（n = 8134）、股骨颈（n = 32,735）、腰椎（n = 28,498）和足跟（n = 265,627）的遗传汇总数据作为结果。逆方差加权法未发现低钠血症对骨密度有任何因果效应。此外，其他方法，如MR-Egger法、加权中位数法、简单模式法和加权模式法，也未显示低钠血症与骨密度之间存在因果关系的证据。多效性和异质性分析表明，MR研究结果具有稳健性。低钠血症与骨质疏松症之间不存在显著的因果关系。先前观察到的关联可能是由于混杂因素所致。低钠血症不太可能是骨质疏松症的一个因果因素。
