Elgebaly Manar, Farrag Wael, Shalaby Khaled, Elserougy Hesham, Negm Manal Saad
Department of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt.
J Investig Med. 2025 Mar;73(3):271-278. doi: 10.1177/10815589241308573. Epub 2025 Jan 9.
Autoimmune thyroid disorders (AITD) are the most common autoimmune human disorders as the thyroid gland is a main target for autoimmunity. The association between rheumatologic and thyroid disorders has long been known, the most common being the association with rheumatoid arthritis. Our study was conducted to screen for the presence of symptoms, signs, and immune markers suggesting the presence of Sjogren's syndrome among patients with autoimmune thyroid disorders. Eighty AITD patients (46 patients with Hashimoto's thyroiditis and 34 patients with Graves' disease) were included in the study and 40 healthy subjects matched age and sex as a control group. The two groups were compared according to 2002 the American-European Consensus Group (AECG) criteria for diagnosis of primary Sjogren's syndrome. 12.5% of AITD patients (n = 10 patients) were diagnosed with Sjogren's syndrome (AITD-SS). Eight out of ten of AITD-SS had Hashimoto's disease while only two had Grave's disease. Anti-Ro was detected in serum of seven patients of the AITD patients with Sjogren syndrome while anti-La was detected in serum of eight patients. The most independent predictors of Sjogren's syndrome in AITD patients are anti-La, ESR, and salivary gland sonographic change. Sjogren's syndrome has been found in patients with AITD, and also patients with AITD have symptoms that mimic sicca disease despite not fulfilling the criteria for diagnosis.
自身免疫性甲状腺疾病（AITD）是最常见的人类自身免疫性疾病，因为甲状腺是自身免疫的主要靶点。风湿性疾病与甲状腺疾病之间的关联早已为人所知，最常见的是与类风湿关节炎的关联。我们开展这项研究是为了筛查自身免疫性甲状腺疾病患者中提示存在干燥综合征的症状、体征和免疫标志物。80例AITD患者（46例桥本甲状腺炎患者和34例格雷夫斯病患者）被纳入研究，40名年龄和性别匹配的健康受试者作为对照组。根据2002年美国-欧洲共识小组（AECG）原发性干燥综合征诊断标准对两组进行比较。12.5%的AITD患者（n = 10例）被诊断为干燥综合征（AITD-SS）。10例AITD-SS患者中有8例患有桥本氏病，只有2例患有格雷夫斯病。在患有干燥综合征的AITD患者血清中，7例检测到抗Ro，8例检测到抗La。AITD患者中干燥综合征最独立的预测因素是抗La、血沉和唾液腺超声改变。在AITD患者中发现了干燥综合征，并且AITD患者也有类似干燥病的症状，尽管不符合诊断标准。
