Wu Meng-Bo, Wang Rui, Zeng Qing-Tian, Shuai Wen-Liang, Zhang Hang-Cheng, Dong Yi-Fei
Department of Cardiovascular Medicine, the 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Jiangxi Key Laboratory of Molecular Medicine, Nanchang, Jiangxi, China.
J Clin Hypertens (Greenwich). 2025 Jan;27(1):e14960. doi: 10.1111/jch.14960. Epub 2024 Dec 17.
The relationship between the uric acid to high-density lipoprotein cholesterol ratio (UHR) and kidney function in patients with primary aldosteronism (PA) is unclear. Therefore, this research explored the link between the UHR and kidney function in PAs. This research was conducted at the 2nd Affiliated Hospital of Nanchang University and involved PA individuals hospitalized between October 2017 and April 2022. A total of 653 eligible participants were included in the analysis for this research. The kidney function was assessed by the estimated glomerular filtration rate (eGFR), which is calculated using the modification of diet in renal disease (MDRD) equation. Chronic kidney disease (CKD) was defined as an eGFR <60 mL/min per 1.73 m or the ratio of urine microalbumin to creatinine (UACR) ≥30 mg/g. The study used multivariable-adjusted linear regression analyses to investigate the association between log-transformed UHR levels and, eGFR and CKD. After multivariable adjustments, the results indicated an inverse association between Lg-UHR and eGFR (per SD increment; β: -9.02; 95% CI: -11.59, -6.46). Compared to PA patients with the lowest level of Lg-UHR (T1), patients with the highest level of Lg-UHR (T3) had a lower eGFR (β: -20.14, 95% CI: -26.25, -14.04). Conversely, Lg-UHR and CKD showed a positive association cross-sectionally (per SD increment; OR: 1.67; 95% CI: 1.26, 2.23). Compared to PA patients in T1 level, patients in T3 level had a higher prevalence of CKD (OR: 2.52, 95% CI: 1.26, 5.05). In patients with PA, UHR is inversely associated with eGFR and positively associated with CKD.
原发性醛固酮增多症（PA）患者尿酸与高密度脂蛋白胆固醇比值（UHR）和肾功能之间的关系尚不清楚。因此，本研究探讨了PA患者中UHR与肾功能之间的联系。本研究在南昌大学第二附属医院开展，纳入了2017年10月至2022年4月期间住院的PA患者。本研究分析共纳入了653名符合条件的参与者。肾功能通过估算肾小球滤过率（eGFR）进行评估，该指标使用肾脏病饮食改良（MDRD）方程计算得出。慢性肾脏病（CKD）定义为eGFR＜60 ml/（min·1.73 m²）或尿微量白蛋白与肌酐比值（UACR）≥30 mg/g。本研究采用多变量调整线性回归分析来研究对数转换后的UHR水平与eGFR和CKD之间的关联。经过多变量调整后，结果显示Lg-UHR与eGFR呈负相关（每标准差增加；β：-9.02；95%置信区间：-11.59，-6.46）。与Lg-UHR水平最低的PA患者（T1）相比，Lg-UHR水平最高的患者（T3）的eGFR较低（β：-20.14，95%置信区间：-26.25，-14.04）。相反，Lg-UHR与CKD在横断面分析中呈正相关（每标准差增加；OR：1.67；95%置信区间：1.26，2.23）。与T1水平的PA患者相比，T3水平的患者CKD患病率更高（OR：2.52，95%置信区间：1.26，5.05）。在PA患者中，UHR与eGFR呈负相关，与CKD呈正相关。
