Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
Department of Endocrinology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
BMC Cardiovasc Disord. 2024 Mar 13;24(1):155. doi: 10.1186/s12872-024-03824-z.
Hyperuricemia and low level of high-density lipoprotein cholesterol (HDL-C) are both risk factors for coronary artery disease (CAD). The uric acid to HDL-C ratio (UHR) has recently been identified as a new inflammatory and metabolic biomarker. However, the relationship between the UHR and coronary culprit plaques has not been fully investigated in patients with acute coronary syndrome (ACS).
A total of 346 patients with ACS were enrolled in this study. Culprit lesion characteristics were assessed by optical coherence tomography (OCT). Logistic regression and linear correlation analyses were performed to assess the association between the UHR and culprit plaques. The predictive value of the UHR was investigated by receiver operating characteristic (ROC) curve analysis.
The percentages of typical culprit plaques, including ruptures, erosions and thrombi, were greater in the high-UHR subgroup than those in the low-UHR subgroup. A positive relationship was also found between the UHR and diameter stenosis (r = 0.160, P = 0.003) and between the UHR and area stenosis (r = 0.145, P = 0.007). The UHR was found to be independently associated with plaque rupture, erosion and thrombus. Furthermore, ROC analysis suggested that the UHR had a better predictive value than low-density lipoprotein cholesterol.
An elevated UHR level was independently related to the occurrence rate of culprit plaques. The UHR is a simple and easily acquired parameter for detecting culprit plaques in patients with ACS.
高尿酸血症和低水平高密度脂蛋白胆固醇（HDL-C）都是冠心病（CAD）的危险因素。尿酸与高密度脂蛋白胆固醇比值（UHR）最近被确定为一种新的炎症和代谢生物标志物。然而，在急性冠脉综合征（ACS）患者中，UHR 与冠脉罪犯斑块之间的关系尚未得到充分研究。
本研究共纳入 346 例 ACS 患者。采用光学相干断层扫描（OCT）评估罪犯病变特征。采用逻辑回归和线性相关分析评估 UHR 与罪犯斑块之间的关系。通过受试者工作特征（ROC）曲线分析探讨 UHR 的预测价值。
高 UHR 亚组中典型罪犯斑块（包括破裂、侵蚀和血栓形成）的比例高于低 UHR 亚组。UHR 与直径狭窄（r=0.160，P=0.003）和面积狭窄（r=0.145，P=0.007）之间呈正相关。UHR 与斑块破裂、侵蚀和血栓形成独立相关。此外，ROC 分析表明 UHR 的预测价值优于低密度脂蛋白胆固醇。
升高的 UHR 水平与罪犯斑块的发生率独立相关。UHR 是检测 ACS 患者罪犯斑块的一种简单且易于获得的参数。
