York J P, Drago J R
J Urol. 1985 Feb;133(2):294-7. doi: 10.1016/s0022-5347(17)48926-9.
The histologic effect of unilateral torsion on the contralateral testicle in adult Noble rats was examined. Utilizing detorsion or orchiectomy at 3 hours and 24 hours after torsion, the effect of early and late treatment of these changes was reviewed. The histologic changes consisted of loss of tubular spermatozoa, clumping of chromatin within the spermatocytes, the presence of Sertoli-only cells, evacuolization of Sertoli cytoplasm and germinal epithelial sloughing. Depression of spermatogenesis and decrease in the mean seminiferous tubular size was seen in the "normal" testicle after unilateral torsion. This effect was negated by early treatment with either orchiectomy or detorsion. Late detorsion does not negate these effects and late orchiectomy only partially negates them. Despite the depressed tubular function, the presence of early spermatogenic elements seen in the majority of the tubules in the "normal" testicle implies the possible reversibility of these changes.
研究了成年诺布尔大鼠单侧睾丸扭转对侧睾丸的组织学影响。在扭转后3小时和24小时进行去扭转或睾丸切除术，回顾了这些改变的早期和晚期治疗效果。组织学变化包括生精小管内精子丢失、精母细胞内染色质凝聚、仅支持细胞的存在、支持细胞胞质空泡化和生精上皮脱落。单侧睾丸扭转后，“正常”睾丸出现生精抑制和生精小管平均大小减小。早期进行睾丸切除术或去扭转可消除这种影响。晚期去扭转不能消除这些影响，晚期睾丸切除术只能部分消除这些影响。尽管生精小管功能受到抑制，但在“正常”睾丸的大多数小管中可见早期生精成分，这意味着这些改变可能具有可逆性。
