Zeng Qiying, Xue Wenjun, Wei Zhicheng, Shen Hangdong, Xu Huajun, Zhu Huaming, Guan Jian, Yi Hongliang, Feng Yunhai, Li Xinyi, Ye Haibo
Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otorhinolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, People's Republic of China.
Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Eighth People's Hospital Affiliated to Jiangsu University, Shanghai, People's Republic of China.
Nat Sci Sleep. 2024 Jul 19;16:989-1000. doi: 10.2147/NSS.S456995. eCollection 2024.
Sleep-disordered breathing is more prevalent in individuals with allergic rhinitis (AR) than in those without AR. In addition to increased risk for sleep-disordered breathing, AR is associated with greater severity of obstructive sleep apnea (OSA) symptoms. The aim of this research study was to evaluate the association of multiple single nucleotide polymorphism (SNP) variations in AR with sleep- and breathing-related parameters in men with OSA.
Men who had complained of snoring were consecutively enrolled in the Shanghai Sleep Health Study of Shanghai Sixth People's Hospital from 2007 to 2018. After rigorous screening, 5322 men were included in the analysis. Anthropometric, fasting biochemical, and polysomnographic parameters, along with 27 AR-associated SNPs were analyzed. The associations between AR-related genetic polymorphisms and OSA were determined via linear, binary, and multinomial logistic regression analyses.
Rs12509403 had significantly positive associations with most sleep-breathing parameters. While the risk for OSA was increased by rs12509403, it was decreased by rs7717955 [odds ratio (OR) = 1.341, 95% confidence interval [CI] = 1.039-1.732, P = 0.024; OR = 0.829, 95% CI = 0.715-0.961, P = 0.013, respectively]. A graded increase in the risk of being in the highest quartile (Q4) vs the reference category (Q1) for sleep breathing indicators, especially REM-AHI and NREM-AHI, was identified by rs12509403 (OR = 1.496, 95% CI = 1.175-1.904, P = 0.001; OR = 1.471, 95% CI = 1.151-1.879, P < 0.001, respectively).
The association of multiple AR SNPs with OSA-related hypoxia and sleep indices provides a genetic explanation for the higher AR susceptibility of OSA patients. Understanding the AR-related genetic underpinnings of OSA may lead to more personalized treatment approaches.
睡眠呼吸障碍在过敏性鼻炎（AR）患者中比在无AR患者中更为普遍。除了睡眠呼吸障碍风险增加外，AR还与阻塞性睡眠呼吸暂停（OSA）症状的更严重程度相关。本研究的目的是评估AR中多个单核苷酸多态性（SNP）变异与OSA男性患者睡眠和呼吸相关参数之间的关联。
2007年至2018年，在上海第六人民医院的上海睡眠健康研究中，连续纳入主诉打鼾的男性。经过严格筛选，5322名男性被纳入分析。分析了人体测量学、空腹生化和多导睡眠图参数，以及27个与AR相关的SNP。通过线性、二元和多项逻辑回归分析确定AR相关基因多态性与OSA之间的关联。
Rs12509403与大多数睡眠呼吸参数有显著正相关。虽然rs12509403增加了OSA风险，但rs7717955降低了该风险[比值比（OR）=1.341，95%置信区间[CI]=1.039 - 1.732，P = 0.024；OR = 0.829，95% CI = 0.715 - 0.961，P = 0.013]。rs12509403确定了睡眠呼吸指标处于最高四分位数（Q4）与参考类别（Q1）相比风险的分级增加，尤其是快速眼动期呼吸暂停低通气指数（REM-AHI）和非快速眼动期呼吸暂停低通气指数（NREM-AHI）（OR = 1.496，95% CI = 1.175 - 1.904，P = 0.001；OR = 1.471，95% CI = 1.151 - 1.879，P < 0.001）。
多个AR SNP与OSA相关的缺氧和睡眠指标之间的关联为OSA患者较高的AR易感性提供了遗传学解释。了解OSA与AR相关的遗传基础可能会带来更个性化的治疗方法。
