中国青少年腭裂患者阻塞性睡眠呼吸暂停相关生活质量与两种心理状态的相关性：一项综合研究。
The correlation between OSA-related quality of life and two mental statuses in adolescent Chinese patients with cleft palate: A comprehensive study.
作者信息
Zong Yuan, Cheng Xu, Xia Weiyao, Xie Zhuojun, Yang Yichun, Shi Bing, Gong Caixia, Huang Hanyao
机构信息
State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases and Department of Oral Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
出版信息
Front Pediatr. 2022 Oct 21;10:985375. doi: 10.3389/fped.2022.985375. eCollection 2022.
OBJECTIVES
To analyze obstructive sleep apnea (OSA)-related quality of life (QoL), the statuses of depression and anxiety, and to reveal the correlation between OSA-related QoL and two mental statuses in Chinese adolescent patients with cleft palate (CP).
METHODS
The Obstructive Sleep Apnea Questionaire-18 (OSA-18), the Generalized Anxiety Disorder Scale (GAD-7) and the Patient Health Questionnaire-9 (PHQ-9) were applied to assess OSA-related QoL and the statuses of anxiety and depression in Chinese adolescent patients with CP, respectively. Non-CP adolescents were also included in the control group. OSA-related QoL and the two mental statuses were compared between the study and control groups. The correlation between the OSA-related QoL and two mental statuses was estimated in Chinese adolescent patients with CP.
RESULTS
A total of 8.7% patients showed a moderate or high impact of OSA on QoL, while all the adolescents from the control group showed little impact. The mean total OSA-18 score of the study group (36.261 ± 13.500) was significantly higher than the control (28.435 ± 8.934). The mean PHQ-9 scores of the study group and the control group were statistically different (3.957 vs. 2.113). The GAD-7 score in the study group was slightly higher than the control group (3.043 vs. 2.194), while the proportion of moderate-severe anxiety in the study group was relatively larger than that in the control group (6.5% vs. 1.6%). Moreover, there was a positive correlation between the OSA-related QoL and the statuses of anxiety and depression respectively, and the differences in GAD-7 and PHQ-9 scores between the moderate or high impact group and the little impact group were statistically significant.
CONCLUSION
Chinese adolescents with CP reported a rate of moderate or high impact of OSA on QoL of 8.7%, which was significantly higher than adolescents without CP. The OSA-related QoL was worse and depression was severer in Chinese CP adolescents than in the control, while anxiety and depression in Chinese CP adolescents were associated with OSA-related QoL.
目的
分析中国腭裂青少年患者阻塞性睡眠呼吸暂停（OSA）相关的生活质量（QoL）、抑郁和焦虑状况，并揭示OSA相关QoL与这两种心理状态之间的相关性。
方法
分别应用阻塞性睡眠呼吸暂停问卷18（OSA - 18）、广泛性焦虑障碍量表（GAD - 7）和患者健康问卷9（PHQ - 9）评估中国腭裂青少年患者OSA相关的QoL以及焦虑和抑郁状况。对照组纳入非腭裂青少年。比较研究组和对照组之间OSA相关的QoL以及这两种心理状态。评估中国腭裂青少年患者中OSA相关QoL与这两种心理状态之间的相关性。
结果
共有8.7%的患者显示OSA对QoL有中度或高度影响，而对照组所有青少年显示影响较小。研究组的OSA - 18总分均值（36.261±13.500）显著高于对照组（28.435±8.934）。研究组和对照组的PHQ - 9得分均值在统计学上有差异（3.957对2.113）。研究组的GAD - 7得分略高于对照组（3.043对2.194），而研究组中重度焦虑的比例相对高于对照组（6.5%对1.6%）。此外，OSA相关QoL与焦虑和抑郁状况之间分别存在正相关，中度或高度影响组与轻度影响组之间GAD - 7和PHQ - 9得分的差异具有统计学意义。
结论
中国腭裂青少年中，有8.7%的患者报告OSA对QoL有中度或高度影响，这一比例显著高于非腭裂青少年。中国腭裂青少年中与OSA相关的QoL更差，抑郁更严重，而中国腭裂青少年的焦虑和抑郁与OSA相关的QoL有关。
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