Hamad Adel Khalifa S
Department of Electrophysiology, Mohammed Bin Khalifa Bin Salman Al Khalifa Cardiac Centre, Awali, Bahrain.
J Saudi Heart Assoc. 2024 Nov 16;36(4):335-348. doi: 10.37616/2212-5043.1402. eCollection 2024.
Caffeine is a frequently consumed stimulant in different foods and beverages: coffee, tea, chocolate, sodas, and energy drinks. While its effects on the cardiovascular system have been extensively studied, there remains controversy surrounding its potential risks, particularly in patients with heart disease. This review provides a complete overview of caffeine's pharmacological properties, sources, and cardiovascular effects, particularly emphasizing its arrhythmogenic potential. The proarrhythmic potential of caffeine, particularly on atrial fibrillation and ventricular arrhythmias, is conducted. It explains the mechanism of action, including adenosine receptor antagonism, phosphodiesterase inhibition, calcium mobilization, and catecholamine release of caffeine. Epidemiological evidence and mechanistic insights are provided for both conditions, and caffeine consumption's incidence, triggers, and impact on premature ventricular contractions are explained. It emphasizes the need for more research to comprehend the complex relationship between caffeine consumption and cardiovascular health, specifically in high-risk populations.
咖啡因是一种在不同食物和饮料中经常食用的兴奋剂，如咖啡、茶、巧克力、汽水和能量饮料。虽然其对心血管系统的影响已得到广泛研究，但围绕其潜在风险仍存在争议，尤其是在心脏病患者中。本综述全面概述了咖啡因的药理特性、来源及其心血管效应，特别强调了其致心律失常的潜力。研究了咖啡因的促心律失常潜力，特别是对心房颤动和室性心律失常的影响。阐述了其作用机制，包括腺苷受体拮抗、磷酸二酯酶抑制、钙动员以及咖啡因的儿茶酚胺释放。针对这两种情况提供了流行病学证据和机制见解，并解释了咖啡因摄入对室性早搏的发生率、触发因素及影响。强调需要进行更多研究以理解咖啡因摄入与心血管健康之间的复杂关系，特别是在高危人群中。
