Huang Sidan, Zhang Danni, Shi Xuliang, Zhang Yi, Wang Xuesong, She Yanfen, Liang Ce, Li Xinyue, Zaslawski Christopher
School of Acupuncture-Moxibustion and Tuina, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China.
Hebei International Joint Research Center for Dominant Diseases in Chinese Medicine and Acupuncture, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China.
Front Psychiatry. 2024 Dec 2;15:1495418. doi: 10.3389/fpsyt.2024.1495418. eCollection 2024.
The decreased ovarian function has a negative impact on the mental health of women and increases the risk of anxiety and depression. A growing number of clinical studies have demonstrated that acupuncture-related therapies can effectively and safely restore hormone levels and improve ovarian reserve function. However, the effectiveness of acupuncture-related therapies in alleviating anxiety and depression symptoms in patients with ovarian hypofunction has not been thoroughly evaluated. Therefore, this study conducted a systematic review and meta-analysis to assess the impact of the different acupuncture-related therapies on the mental health of patients with ovarian hypofunction.
We comprehensively searched eight famous databases for randomized controlled trials up to October 30, 2024. Databases include PubMed, Web of Science, EMBASE and Cochrane Library, China Biomedical (CBM), China National Knowledge Infrastructure (CNKI), Wanfang Database and VIP Database.
The study included 12 RCTs, involving 780 patients with ovarian hypofunction, including 403 patients with POI, 297 patients with DOR, and 80 patients with POF. Acupuncture-related therapy was obviously superior to hormone therapy in relieving anxiety symptoms (SMD: -0.90; 95%CI: -1.28, -0.53; <0.000 01) and depressive symptoms (SMD: -0.82; 95% CI: -1.25, -0.40; =0.0001).
Acupuncture-related therapy was more effective than hormone therapy in improving anxiety and depression symptoms in patients with ovarian hypofunction. This study supports the use of acupuncture-related therapies for women experiencing decreased ovarian function associated with mental health issues.
卵巢功能下降对女性心理健康有负面影响，并增加焦虑和抑郁风险。越来越多的临床研究表明，针刺相关疗法可有效且安全地恢复激素水平并改善卵巢储备功能。然而，针刺相关疗法在缓解卵巢功能减退患者焦虑和抑郁症状方面的有效性尚未得到充分评估。因此，本研究进行了一项系统评价和荟萃分析，以评估不同针刺相关疗法对卵巢功能减退患者心理健康的影响。
我们全面检索了8个著名数据库，以查找截至2024年10月30日的随机对照试验。数据库包括PubMed、科学网、EMBASE和考克兰图书馆、中国生物医学文献数据库（CBM）、中国知网（CNKI）、万方数据库和维普数据库。
该研究纳入了12项随机对照试验，涉及780例卵巢功能减退患者，其中包括403例原发性卵巢功能不全患者、297例卵巢储备功能下降患者和80例卵巢早衰患者。针刺相关疗法在缓解焦虑症状（标准化均数差：-0.90；95%置信区间：-1.28，-0.53；<0.00001）和抑郁症状（标准化均数差：-0.82；95%置信区间：-1.25，-0.40；=0.0001）方面明显优于激素疗法。
针刺相关疗法在改善卵巢功能减退患者焦虑和抑郁症状方面比激素疗法更有效。本研究支持将针刺相关疗法用于卵巢功能下降且伴有心理健康问题的女性。
