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通过阳离子纳米颗粒清除游离DNA治疗急性肺损伤。

Treating acute lung injury through scavenging of cell-free DNA by cationic nanoparticles.

作者信息

Huang Ziyan, Wei Cong, Xie Hanbin, Xiao Xue, Wang Tienan, Zhang Yihan, Chen Yongming, Hei Ziqing, Zhao Tianyu, Yao Weifeng

机构信息

Department of Anesthesiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou510630, PR China.

School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, PR China.

出版信息

Mater Today Bio. 2024 Nov 25;29:101360. doi: 10.1016/j.mtbio.2024.101360. eCollection 2024 Dec.

DOI:10.1016/j.mtbio.2024.101360
PMID:39687793
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11648789/
Abstract

Acute lung injury (ALI) and acute respiratory distress syndrome are life-threatening conditions induced by inflammatory responses, in which cell-free DNA (cfDNA) plays a pivotal role. This study investigated the therapeutic potential of biodegradable cationic nanoparticles (cNPs) in alleviating ALI. Using a mouse model of lipopolysaccharide-induced ALI, we examined the impact of intravenously administered cNPs. Our findings indicate that cNPs possess robust DNA binding capability, enhanced accumulation in inflamed lungs, and a favorable safety profile . Furthermore, cNPs attenuate the inflammatory response in LPS-induced ALI mice by scavenging cfDNA, mainly derived from neutrophil extracellular traps, and activating the macrophage-mediated cGAS-STING pathway. The findings suggest a potential treatment for ALI by targeting cfDNA with cNPs. This approach has demonstrated efficacy in mitigating lung injury and merits further exploration.

摘要

急性肺损伤（ALI）和急性呼吸窘迫综合征是由炎症反应引发的危及生命的病症，其中游离DNA（cfDNA）起着关键作用。本研究调查了可生物降解的阳离子纳米颗粒（cNPs）在减轻ALI方面的治疗潜力。使用脂多糖诱导的ALI小鼠模型，我们检测了静脉注射cNPs的影响。我们的研究结果表明，cNPs具有强大的DNA结合能力，在炎症肺组织中积累增强，且安全性良好。此外，cNPs通过清除主要源自中性粒细胞胞外陷阱的cfDNA并激活巨噬细胞介导的cGAS-STING途径，减轻LPS诱导的ALI小鼠的炎症反应。这些发现表明，通过用cNPs靶向cfDNA可能为ALI提供一种治疗方法。这种方法已证明在减轻肺损伤方面有效，值得进一步探索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11648789/d1638698ebd4/gr6.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11648789/f0bb2575b5fe/gr1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11648789/69a81de7b8ee/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11648789/4c4fa9a35db5/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11648789/b767300ef2a1/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11648789/d1638698ebd4/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11648789/9a4c228f44b2/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11648789/49d911e33af4/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11648789/f0bb2575b5fe/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11648789/9c75413d0584/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11648789/69a81de7b8ee/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11648789/4c4fa9a35db5/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11648789/b767300ef2a1/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11648789/d1638698ebd4/gr6.jpg

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本文引用的文献

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The role of neutrophil extracellular traps in acute lung injury.
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