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盐酸加替沙星对植物病原菌具有广谱抗菌活性。

Gatifloxacin hydrochloride confers broad-spectrum antibacterial activity against phytopathogenic bacteria.

作者信息

Huang Yanxia, Peng Bin, Li Chenhui, Wu Yuqin, Zeng Zixian, Tariq Moh, Jiang Lin, Li Shun-Xiang, Wu Dousheng

机构信息

Hunan Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University, Changsha, China.

Hunan Engineering Technology Research Center for Bioactive Substance Discovery of Chinese Medicine, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.

出版信息

Front Microbiol. 2024 Dec 2;15:1504243. doi: 10.3389/fmicb.2024.1504243. eCollection 2024.

DOI:10.3389/fmicb.2024.1504243
PMID:39687870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11648225/
Abstract

Bacterial diseases pose significant threats to agriculture and natural ecosystems, causing substantial crop losses and impacting food security. Until now, there has been a less efficient control strategy against some bacterial diseases such as bacterial wilt, caused by . In this study, we screened a library of 58 microorganism-derived natural products for their antibacterial activity against . Gatifloxacin hydrochloride exhibited the best inhibitory effect with an inhibition rate of 95% at 0.0625 mg/L. Further experiments demonstrate that gatifloxacin hydrochloride inhibits growth in a concentration-dependent manner, with the minimum inhibitory concentration of 0.125 mg/L. Treatment with 0.5 mg/L of gatifloxacin hydrochloride killed more than 95% of bacteria. Gatifloxacin hydrochloride significantly inhibited biofilm formation by . Gatifloxacin hydrochloride also shows good antibacterial activity against pv. DC3000 and pv. . Exogenous application of gatifloxacin hydrochloride suppressed disease development caused by and . In summary, our results demonstrate the great potential of microorganism-derived compounds as broad-spectrum antibacterial compounds, providing alternative ways for the efficient control of bacterial plant diseases.

摘要

细菌性病害对农业和自然生态系统构成重大威胁，导致大量作物损失并影响粮食安全。到目前为止，针对一些细菌性病害，如由[未提及病原菌名称]引起的青枯病，一直缺乏高效的防治策略。在本研究中，我们筛选了一个包含58种微生物来源天然产物的文库，以检测它们对[未提及病原菌名称]的抗菌活性。盐酸加替沙星表现出最佳抑制效果，在0.0625mg/L时抑制率达95%。进一步实验表明，盐酸加替沙星以浓度依赖方式抑制[未提及病原菌名称]生长，最低抑菌浓度为0.125mg/L。用0.5mg/L盐酸加替沙星处理可杀死超过95%的细菌。盐酸加替沙星显著抑制[未提及病原菌名称]生物膜形成。盐酸加替沙星对[未提及病原菌名称]丁香假单胞菌番茄致病变种DC3000和[未提及病原菌名称]辣椒斑点病菌致病变种也表现出良好抗菌活性。外源施用盐酸加替沙星可抑制由[未提及病原菌名称]和[未提及病原菌名称]引起的病害发展。总之，我们的结果证明了微生物来源化合物作为广谱抗菌化合物具有巨大潜力，为有效防治植物细菌性病害提供了替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5d/11648225/58a42e09074d/fmicb-15-1504243-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5d/11648225/e8bfe66b5eb3/fmicb-15-1504243-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5d/11648225/6dc8a264409e/fmicb-15-1504243-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5d/11648225/d25b4d3a73bc/fmicb-15-1504243-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5d/11648225/037188d44fcf/fmicb-15-1504243-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5d/11648225/f39827823019/fmicb-15-1504243-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5d/11648225/c751993b26e6/fmicb-15-1504243-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5d/11648225/bece36f9a8f7/fmicb-15-1504243-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5d/11648225/58a42e09074d/fmicb-15-1504243-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5d/11648225/e8bfe66b5eb3/fmicb-15-1504243-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5d/11648225/6dc8a264409e/fmicb-15-1504243-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5d/11648225/d25b4d3a73bc/fmicb-15-1504243-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5d/11648225/037188d44fcf/fmicb-15-1504243-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5d/11648225/f39827823019/fmicb-15-1504243-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5d/11648225/c751993b26e6/fmicb-15-1504243-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5d/11648225/bece36f9a8f7/fmicb-15-1504243-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5d/11648225/58a42e09074d/fmicb-15-1504243-g008.jpg

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本文引用的文献

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Heliyon. 2024 Apr 4;10(7):e29128. doi: 10.1016/j.heliyon.2024.e29128. eCollection 2024 Apr 15.
2
A screening identifies harmine as a novel antibacterial compound against .一项筛选将 harmine 鉴定为一种针对……的新型抗菌化合物。 （原句中“against”后面缺少具体对象）
Front Microbiol. 2023 Sep 5;14:1269567. doi: 10.3389/fmicb.2023.1269567. eCollection 2023.
3
Environmental pollutants and their effects on human health.
环境污染物及其对人类健康的影响。
Heliyon. 2023 Aug 25;9(9):e19496. doi: 10.1016/j.heliyon.2023.e19496. eCollection 2023 Sep.
4
Natural antimicrobials from plants: Recent advances and future prospects.植物来源的天然抗菌剂：最新进展与未来展望。
Food Chem. 2024 Jan 30;432:137231. doi: 10.1016/j.foodchem.2023.137231. Epub 2023 Aug 24.
5
: An Arsenal of Virulence Strategies and Prospects for Resistance.毒力策略库与抗药性前景
Annu Rev Phytopathol. 2023 Sep 5;61:25-47. doi: 10.1146/annurev-phyto-021622-104551. Epub 2023 Jul 28.
6
Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018-2022.近年来发现的植物源抗菌天然产物在对抗抗微生物药物耐药性病原体方面的进展：2018-2022 年的研究进展。
Nat Prod Rep. 2023 Jul 19;40(7):1271-1290. doi: 10.1039/d2np00090c.
7
Climate change impacts on plant pathogens, food security and paths forward.气候变化对植物病原体、粮食安全的影响及前进道路。
Nat Rev Microbiol. 2023 Oct;21(10):640-656. doi: 10.1038/s41579-023-00900-7. Epub 2023 May 2.
8
Biopesticides as a promising alternative to synthetic pesticides: A case for microbial pesticides, phytopesticides, and nanobiopesticides.生物农药作为合成农药的一种有前景的替代品：以微生物农药、植物源农药和纳米生物农药为例
Front Microbiol. 2023 Feb 16;14:1040901. doi: 10.3389/fmicb.2023.1040901. eCollection 2023.
9
Evasion of plant immunity by microbial pathogens.微生物病原体对植物免疫的逃避。
Nat Rev Microbiol. 2022 Aug;20(8):449-464. doi: 10.1038/s41579-022-00710-3. Epub 2022 Mar 16.
10
Global invasion history of the emerging plant pathogen Phytophthora multivora.新兴植物病原菌多黏菌属的全球入侵史。
BMC Genomics. 2022 Feb 22;23(1):153. doi: 10.1186/s12864-022-08363-5.