丹麦腮腺淋巴瘤：一项全国性队列研究。

Lymphomas of the Parotid Gland in Denmark: A Nationwide Cohort Study.

作者信息

Al-Shahrestani Fahd, Al-Khafaf Ahmed Ehsan, Asheer Zain, Jelicic Jelena, Chanchiri Iman, Blocher Catharina E, Aalling Sørensen Anne Kathrine, Møller Pedersen Lars, Gjerdrum Lise Mette Rahbek, Heegaard Steffen, Homøe Preben

机构信息

Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Køge, Denmark.

Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

出版信息

Laryngoscope. 2025 Apr;135(4):1391-1400. doi: 10.1002/lary.31929. Epub 2024 Dec 17.

DOI:10.1002/lary.31929

PMID:39688162

Abstract

OBJECTIVE

We examined the epidemiology of parotid gland lymphomas (PGL), the incidence, survival rates, clinical features, and association with primary Sjögren's syndrome (pSS).

METHODS

This retrospective nationwide cohort study analyzed data from Danish patients diagnosed with PGL between 2000 and 2020. Data were collected from medical records, the National Pathology Register, and the Danish lymphoma database. Statistical analyses included Kaplan-Meier curves, log-rank tests, and Cox proportional hazards models.

RESULTS

A total of 433 patients were included. The incidence rate was 0.39 per 100,000 person-years, with PGL constituting 1.9% of all non-Hodgkins lymphoma in Denmark. The average annual incidence was 2.7% (incidence rate ratio = 1.027, p < 0.01). Follicular lymphoma (FL) was the most common subtype with 154 cases (35.6%), followed by large B-cell lymphoma (LBCL) with 119 cases (27.5%), and extranodal marginal zone lymphoma (EMZL) with 84 cases (19.4%). The median overall survival (OS) for FL was 9.5 years (95% CI 6.9-10.2), with 5-year and 10-year OS rates of 70% and 44%, respectively. For LBCL, the median OS was 7.8 years (95% CI 5.0-8.8), with 5-year and 10-year OS rates of 59% and 33%. EMZL had a median OS of 12.8 years (95% CI 9.0-16.3), with 5-year and 10-year OS rate of 83% and 55%. EMZL was significantly associated with pSS, relative risk 21.97 (95% CI 2.81-171.53). Advanced age, B symptoms, and elevated LDH levels were significantly linked to poorer overall survival.

CONCLUSION

This study offers new epidemiological, clinical, and prognostic insights, with a focus on their association with pSS.

LEVEL OF EVIDENCE

3 Laryngoscope, 135:1391-1400, 2025.

摘要

目的

我们研究了腮腺淋巴瘤（PGL）的流行病学、发病率、生存率、临床特征以及与原发性干燥综合征（pSS）的关联。

方法

这项全国性回顾性队列研究分析了2000年至2020年间丹麦诊断为PGL的患者数据。数据收集自医疗记录、国家病理学登记册和丹麦淋巴瘤数据库。统计分析包括Kaplan-Meier曲线、对数秩检验和Cox比例风险模型。

结果

共纳入433例患者。发病率为每10万人年0.39例，PGL占丹麦所有非霍奇金淋巴瘤的1.9%。年平均发病率为2.7%（发病率比=1.027，p<0.01）。滤泡性淋巴瘤（FL）是最常见的亚型，有154例（35.6%），其次是大B细胞淋巴瘤（LBCL），有119例（27.5%），以及结外边缘区淋巴瘤（EMZL），有84例（19.4%）。FL的中位总生存期（OS）为9.5年（95%CI 6.9-10.2），5年和10年OS率分别为70%和44%。对于LBCL，中位OS为7.8年（95%CI 5.0-8.8），5年和10年OS率分别为59%和33%。EMZL的中位OS为12.8年（95%CI 9.0-16.3），5年和10年OS率分别为83%和55%。EMZL与pSS显著相关，相对风险为21.97（95%CI 2.81-171.53）。高龄、B症状和乳酸脱氢酶水平升高与较差的总生存期显著相关。