Section of Otolaryngology, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA.
Laryngoscope. 2013 May;123(5):1199-203. doi: 10.1002/lary.23901. Epub 2013 Apr 10.
OBJECTIVES/HYPOTHESIS: Assess the demographic, clinical, and pathologic features of patients with parotid gland lymphoma and their prognostic importance using US population-based data.
Retrospective cohort study.
Patients were selected from the Surveillance, Epidemiology, and End Results program database between the years of 1973 and 2008, and individual characteristics were compared using univariate and multivariate Cox proportional hazards models. Kaplan-Meier survival curves were constructed and log-rank tests were performed.
We identified 2,140 patients with primary parotid gland lymphoma. Hodgkin lymphoma was found in 3.5% of patients. More common were non-Hodgkin lymphoma subtypes: marginal zone B-cell lymphoma, follicular lymphoma, and diffuse large B cell lymphoma accounted for 27.9%, 25.8%, and 23.7% of cases, respectively. Survival was decreased with patient age over 50 years, increasing stage, male gender, non-Hodgkin histology, and status other than married. Of the patients, 72.0% received some form of surgery, and 136 patients had facial nerve sacrifice during parotidectomy.
Non-Hodgkin lymphoma is the predominant type of lymphoma seen in the parotid gland. Patient and histologic features determine survival, and surgery is often performed. Facial nerve sacrifice, which is contraindicated given the systemic nature of lymphoma and the role of chemotherapy and radiation in its treatment, is reported in 6.4% of patients with parotid gland lymphoma.
2b.
目的/假设：利用美国人口统计学数据，评估腮腺淋巴瘤患者的人口统计学、临床和病理特征及其预后意义。
回顾性队列研究。
从 1973 年至 2008 年的监测、流行病学和最终结果计划数据库中选择患者，使用单变量和多变量 Cox 比例风险模型比较个体特征。绘制 Kaplan-Meier 生存曲线并进行对数秩检验。
我们确定了 2140 例原发性腮腺淋巴瘤患者。3.5%的患者患有霍奇金淋巴瘤。更常见的是非霍奇金淋巴瘤亚型：边缘区 B 细胞淋巴瘤、滤泡性淋巴瘤和弥漫性大 B 细胞淋巴瘤分别占 27.9%、25.8%和 23.7%。生存时间随着患者年龄超过 50 岁、分期增加、男性、非霍奇金组织学和已婚状态而降低。72.0%的患者接受了某种形式的手术，136 例腮腺切除术时牺牲了面神经。
非霍奇金淋巴瘤是腮腺中主要的淋巴瘤类型。患者和组织学特征决定生存，手术常进行。面神经牺牲，由于淋巴瘤的全身性以及化疗和放疗在其治疗中的作用，在腮腺淋巴瘤患者中报告的比例为 6.4%。
2b。
