Cui Zhiyue, He Jian, Li An, Wang Junqiang, Yang Yijian, Wang Kaiyue, Liu Zhikun, Ouyang Qian, Su Zhangjie, Hu Pingsheng, Xiao Gelei
Department of Diagnostic Radiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan Province, China.
Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Neural Regen Res. 2026 Feb 1;21(2):636-647. doi: 10.4103/NRR.NRR-D-24-00963. Epub 2024 Dec 16.
A large body of evidence has highlighted the role of non-coding RNAs in neurodevelopment and neuroinflammation. This evidence has led to increasing speculation that non-coding RNAs may be involved in the pathophysiological mechanisms underlying hydrocephalus, one of the most common neurological conditions worldwide. In this review, we first outline the basic concepts and incidence of hydrocephalus along with the limitations of existing treatments for this condition. Then, we outline the definition, classification, and biological role of non-coding RNAs. Subsequently, we analyze the roles of non-coding RNAs in the formation of hydrocephalus in detail. Specifically, we have focused on the potential significance of non-coding RNAs in the pathophysiology of hydrocephalus, including glymphatic pathways, neuroinflammatory processes, and neurological dysplasia, on the basis of the existing evidence. Lastly, we review the potential of non-coding RNAs as biomarkers of hydrocephalus and for the creation of innovative treatments.
大量证据凸显了非编码RNA在神经发育和神经炎症中的作用。这些证据引发了越来越多的猜测，即非编码RNA可能参与了脑积水（全球最常见的神经系统疾病之一）的病理生理机制。在本综述中，我们首先概述脑积水的基本概念、发病率以及现有治疗方法的局限性。然后，我们概述非编码RNA的定义、分类和生物学作用。随后，我们详细分析非编码RNA在脑积水形成中的作用。具体而言，基于现有证据，我们重点关注了非编码RNA在脑积水病理生理学中的潜在意义，包括类淋巴途径、神经炎症过程和神经发育异常。最后，我们综述了非编码RNA作为脑积水生物标志物以及用于创新治疗的潜力。
