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Alpha-synuclein-induced upregulation of SKI family transcriptional corepressor 1: a new player in aging & Parkinson's disease?

作者信息

Barrett Lauren, Bevans Rebekah, Sullivan Aideen M, Collins Louise M, O'Keeffe Gerard W

机构信息

Department of Anatomy and Neuroscience, School of Medicine, University College Cork, Cork, Ireland (Barrett L, Bevans R, Collins LM, O'Keeffe GW).

Department of Pharmacology and Therapeutics, School of Medicine, University College Cork, Cork, Ireland (Sullivan AM).

出版信息

Neural Regen Res. 2024 Dec 16;21(1):320-1. doi: 10.4103/NRR.NRR-D-24-01156.

DOI:10.4103/NRR.NRR-D-24-01156
PMID:39688564
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12094555/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3894/12094555/42c1e1b36126/NRR-21-320-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3894/12094555/42c1e1b36126/NRR-21-320-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3894/12094555/42c1e1b36126/NRR-21-320-g001.jpg

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本文引用的文献

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Nature. 2024 May;629(8011):402-409. doi: 10.1038/s41586-024-07317-z. Epub 2024 Apr 17.
2
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Aging Cell. 2024 Jun;23(6):e14155. doi: 10.1111/acel.14155. Epub 2024 Mar 26.
3
The projection-specific signals that establish functionally segregated dopaminergic synapses.
建立功能分离的多巴胺能突触的投射特异性信号。
Cell. 2023 Aug 31;186(18):3845-3861.e24. doi: 10.1016/j.cell.2023.07.023. Epub 2023 Aug 16.
4
Growth differentiation factor 5 exerts neuroprotection in an α-synuclein rat model of Parkinson's disease.生长分化因子5在帕金森病α-突触核蛋白大鼠模型中发挥神经保护作用。
Brain. 2021 Mar 3;144(2):e14. doi: 10.1093/brain/awaa367.
5
BMP5/7 protect dopaminergic neurons in an α-synuclein mouse model of Parkinson's disease.骨形态发生蛋白5/7在帕金森病α-突触核蛋白小鼠模型中保护多巴胺能神经元。
Brain. 2021 Mar 3;144(2):e15. doi: 10.1093/brain/awaa368.
6
SKOR1 has a transcriptional regulatory role on genes involved in pathways related to restless legs syndrome.SKOR1 在与不宁腿综合征相关途径的基因转录调控中起作用。
Eur J Hum Genet. 2020 Nov;28(11):1520-1528. doi: 10.1038/s41431-020-0670-4. Epub 2020 Jun 22.
7
Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway.α-突触核蛋白诱导的线粒体功能障碍是通过依赖于 SIRT3 的途径介导的。
Mol Neurodegener. 2020 Jan 13;15(1):5. doi: 10.1186/s13024-019-0349-x.
8
BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons and in Human Induced Pluripotent and Neural Stem Cells.BMP/SMAD 通路促进中脑多巴胺能神经元的神经发生，以及在人诱导多能干细胞和神经干细胞中。
J Neurosci. 2018 Feb 14;38(7):1662-1676. doi: 10.1523/JNEUROSCI.1540-17.2018. Epub 2018 Jan 10.
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Genetics of restless legs syndrome: An update.不宁腿综合征的遗传学：最新进展。
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