Nakamura M
Jpn Circ J. 1985 Jan;49(1):1-12. doi: 10.1253/jcj.49.1.
As one of the cause of acute myocardial ischemia, coronary vasospasm has attracted attention increasingly in clinical cardiology. We developed animal model of coronary vasospasm associated with transient myocardial ischemia by administration of histamine or serotonin in atherosclerotic miniature swine. Early systolic dysfunction as well as subendocardial NADH production of the ischemic region occurred within 10 sec after coronary occlusion, but ST segment started to elevate around 30 sec after occlusion in the isolated rat heart. As the important determinant factors of myocardial infarct size, the preocclusive perfusion area as well as collateral flow area could be measured quantitatively by use of double isotopes autoradiograms, and the close correlation was found between the salvaged area and collateral flow area in dogs. An importance of advancement in basic cardiology and development of new research techniques have been emphasized.
作为急性心肌缺血的病因之一，冠状动脉痉挛在临床心脏病学中越来越受到关注。我们通过给动脉粥样硬化小型猪注射组胺或血清素，建立了与短暂性心肌缺血相关的冠状动脉痉挛动物模型。在离体大鼠心脏中，冠状动脉闭塞后10秒内缺血区域出现早期收缩功能障碍以及心内膜下烟酰胺腺嘌呤二核苷酸（NADH）生成，但ST段在闭塞后约30秒开始抬高。作为心肌梗死面积的重要决定因素，可通过使用双同位素自动射线照相术定量测量闭塞前灌注区域以及侧支血流区域，并且在犬类中发现挽救区域与侧支血流区域之间存在密切相关性。已强调了基础心脏病学进展和新研究技术发展的重要性。
