Neill W A, Wharton T P, Fluri-Lundeen J, Cohen I S
N Engl J Med. 1980 May 22;302(21):1157-62. doi: 10.1056/NEJM198005223022101.
We used angiography in a prospective study of the coronary circulation in patients with acute coronary insufficiency. Reversible ST-T changes during the acute illness corresponded anatomically with severely narrowed coronary arteries (80 to 95 per cent stenosis). Angiograms repeated four months later showed new complete occlusions in nine of 30 severely stenotic arteries. Eight of the new occlusions occurred in severely narrowed arteries previously correlated with regional ST-T changes. Six patients had myocardial infarctions, five of which corresponded with the site of a new occlusion. These results provide indirect evidence that the acute coronary-insufficiency syndrome commonly represents intermittent transient coronary-artery occlusion and a threat of new permanent occlusion of the same artery. Myocardial infarction in these patients appeared to occur as a complication of the new occlusion.
我们在一项关于急性冠状动脉供血不足患者冠状动脉循环的前瞻性研究中使用了血管造影术。急性发病期间可逆的ST-T改变在解剖学上与严重狭窄的冠状动脉（80%至95%狭窄）相对应。四个月后重复进行的血管造影显示，30条严重狭窄动脉中有9条出现了新的完全闭塞。其中8条新闭塞发生在先前与局部ST-T改变相关的严重狭窄动脉中。6例患者发生了心肌梗死，其中5例与新闭塞部位相对应。这些结果提供了间接证据，表明急性冠状动脉供血不足综合征通常表现为间歇性短暂冠状动脉闭塞以及同一动脉新的永久性闭塞的威胁。这些患者的心肌梗死似乎是新闭塞的并发症。
