Aderinto Nicholas, Kokori Emmanuel, Olatunji Gbolahan, Ogieuhi Ikponmwosa Jude, Abraham Israel Charles, Ukoaka Bonaventure Michael, Babalola Adetola Emmanuel, Adebayo Yewande Abigail, Ezeano Chimezirim, Oyewo Oluwaseun, Adeshina Ganiyat Adekemi
Department of Medicine and Surgery, Ladoke Akintola University Teaching Hospital, Ogbomoso, Nigeria.
Department of Medicine and Surgery, University of Ilorin, Ilorin, Nigeria.
J Assist Reprod Genet. 2025 Mar;42(3):697-706. doi: 10.1007/s10815-024-03348-7. Epub 2024 Dec 17.
This review investigated the current research on the association between in vitro fertilization and children's neurocognitive development. Twenty studies were analyzed, encompassing over 23,000 children conceived through IVF, and compared to those conceived naturally. The findings on overall cognitive function were mixed, as measured by IQ. Some studies showed no significant differences between IVF and naturally conceived children, while others suggested slight variations. There is emerging evidence that IVF might correlate with specific cognitive domains like language and motor skills, although more research is needed. Several established factors, including maternal age, education level, and birth weight, are associated with children's cognitive development, regardless of conception method. Future research should explore how these factors interact with IVF and investigate a broader range of cognitive domains. Socioeconomic background and parental involvement are essential considerations for understanding a child's developmental trajectory. The inconclusive nature of some findings highlights the need for further research with larger sample sizes, more extended follow-up periods, and robust methodologies. This research has potential implications for parents considering IVF or ICSI, healthcare professionals providing guidance, and future efforts to tailor support systems for children conceived through assisted conception techniques. Open communication about the current state of knowledge and responsible communication of research findings is crucial.
本综述调查了目前关于体外受精与儿童神经认知发育之间关联的研究。分析了20项研究，涵盖了超过23000名通过体外受精受孕的儿童，并与自然受孕的儿童进行了比较。通过智商衡量的总体认知功能的研究结果不一。一些研究表明，体外受精儿童与自然受孕儿童之间没有显著差异，而另一些研究则表明存在细微差异。有新证据表明，体外受精可能与语言和运动技能等特定认知领域相关，不过仍需要更多研究。几个既定因素，包括母亲年龄、教育水平和出生体重，都与儿童的认知发育有关，无论受孕方式如何。未来的研究应探索这些因素如何与体外受精相互作用，并研究更广泛的认知领域。社会经济背景和父母参与是理解儿童发育轨迹的重要考虑因素。一些研究结果的不确定性凸显了进行更大样本量、更长随访期和更可靠方法的进一步研究的必要性。这项研究对考虑体外受精或卵胞浆内单精子注射的父母、提供指导的医疗保健专业人员以及未来为通过辅助受孕技术受孕的儿童量身定制支持系统的努力都有潜在影响。关于当前知识状态的开放沟通以及对研究结果的负责任沟通至关重要。
