Jose B, Perkins P L, Kays H, Chu A M, Sharma S C
J Surg Oncol. 1985 Jan;28(1):1-3. doi: 10.1002/jso.2930280102.
This study is a review of 66 patients with a diagnosis of testicular seminoma, treated at the Department of Radiation Oncology, University of Louisville, from 1959 to 1978. Sixty-four of the patients were diagnosed as pure seminomas and two as spermatocytic type. The age of the patients ranged from 16 to 75 years with a median of 39. Fifty-four patients (82%) presented with swelling or mass in the testis, 7 patients with pain, 1 patient with hydrocele, and 4 patients had seminoma diagnosed incidentally. The distribution was equal for both right and left sides. There were 39 (59%) and 27 (41%) patients in stages I and II, respectively. All stage I patients received only infradiaphragmatic irradiation by a "hockey stick" field, and the majority of them received a dose of 3,200-3,600 rads in 3-4 weeks time. Stage II patients received elective irradiation to the mediastinum and neck region, in addition to the infradiaphragmatic irradiation. The 5-year actuarial survival rates for stage I and II seminomas are 96% and 92%, respectively. There were no serious complications during follow-up. The role of elective irradiation in stage I disease is discussed with a brief review of the literature.
本研究回顾了1959年至1978年在路易斯维尔大学放射肿瘤学系接受治疗的66例诊断为睾丸精原细胞瘤的患者。其中64例患者被诊断为纯精原细胞瘤，2例为精母细胞型。患者年龄在16岁至75岁之间，中位数为39岁。54例患者（82%）表现为睾丸肿胀或肿块，7例患者有疼痛，1例患者有鞘膜积液，4例患者为偶然诊断出精原细胞瘤。左右两侧分布均等。I期和II期患者分别有39例（59%）和27例（41%）。所有I期患者仅通过“曲棍球棒”野接受膈下照射，其中大多数患者在3至4周内接受了3200 - 3600拉德的剂量。II期患者除接受膈下照射外，还接受纵隔和颈部区域的选择性照射。I期和II期精原细胞瘤的5年精算生存率分别为96%和92%。随访期间无严重并发症。结合文献简要回顾，讨论了I期疾病中选择性照射的作用。
