Hommerich C P
Laryngol Rhinol Otol (Stuttg). 1985 Jan;64(1):25-31.
Adenocarcinomas of the larynx are rare. They may arise primarily, but can also be of metastatic origin. The tissue of the first biopsy is often insufficient to assume one of these two possibilities with a probability high enough for designing a therapeutic concept. In two cases of laryngeal adenocarcinomas, large series of laryngeal sections were made. With these sections, we were able to show that some additional histologic criteria ascertained thereby, will contribute towards a safer decision for or against a primary adenocarcinoma. Special attention was given to the varying grades of differentiation and modes of growth. Adenomatous structures, which may represent the matrix of the tumour, and premalignant stages, such as dysplasia or in situ carcinoma, were also looked for. Whenever the decision primary versus metastatic growth is clinically relevant, additional biopsies from the tumour's neighbourhood are, therefore, recommended.
喉腺癌很罕见。它们可能原发产生，但也可能是转移性的。首次活检的组织往往不足以在两种可能性中做出判断，以确定足够高的概率来设计治疗方案。在两例喉腺癌病例中，制作了大量的喉部切片。通过这些切片，我们能够表明由此确定的一些额外的组织学标准，将有助于更安全地决定是否为原发性腺癌。特别关注了不同的分化程度和生长方式。还寻找了可能代表肿瘤基质的腺瘤结构以及癌前阶段，如发育异常或原位癌。因此，每当原发性生长与转移性生长的判断在临床上具有相关性时，建议从肿瘤周围进行额外的活检。
