四氯化碳诱导的肝细胞脂蛋白分泌抑制：在此类损伤早期高尔基体的功能损害。

Carbon tetrachloride-induced inhibition of hepatocyte lipoprotein secretion: functional impairment of Golgi apparatus in the early phases of such injury.

作者信息

Poli G, Chiarpotto E, Albano E, Cottalasso D, Nanni G, Marinari U M, Bassi A M, Dianzani M U

出版信息

Life Sci. 1985 Feb 11;36(6):533-9. doi: 10.1016/0024-3205(85)90634-4.

Abstract

Functional change of liver Golgi apparatus during carbon tetrachloride (CCl4) poisoning was demonstrated both in rat isolated hepatocytes and in the whole animal. The "in vitro" experimental model provided evidence of Golgi derangement early after giving the haloalkane. The "in vivo" analyses also showed that such an alteration involves both formative and secretory sides of the subcellular structure.

摘要

在大鼠分离的肝细胞和整个动物体内均证实了四氯化碳（CCl4）中毒期间肝脏高尔基体的功能变化。“体外”实验模型提供了给予卤代烷后早期高尔基体紊乱的证据。“体内”分析还表明，这种改变涉及亚细胞结构的形成和分泌两个方面。