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四氯化碳诱导的肝细胞脂蛋白分泌抑制：在此类损伤早期高尔基体的功能损害。

Carbon tetrachloride-induced inhibition of hepatocyte lipoprotein secretion: functional impairment of Golgi apparatus in the early phases of such injury.

作者信息

Poli G, Chiarpotto E, Albano E, Cottalasso D, Nanni G, Marinari U M, Bassi A M, Dianzani M U

出版信息

Life Sci. 1985 Feb 11;36(6):533-9. doi: 10.1016/0024-3205(85)90634-4.

DOI:10.1016/0024-3205(85)90634-4
PMID:3968976
Abstract

Functional change of liver Golgi apparatus during carbon tetrachloride (CCl4) poisoning was demonstrated both in rat isolated hepatocytes and in the whole animal. The "in vitro" experimental model provided evidence of Golgi derangement early after giving the haloalkane. The "in vivo" analyses also showed that such an alteration involves both formative and secretory sides of the subcellular structure.

摘要

在大鼠分离的肝细胞和整个动物体内均证实了四氯化碳（CCl4）中毒期间肝脏高尔基体的功能变化。“体外”实验模型提供了给予卤代烷后早期高尔基体紊乱的证据。“体内”分析还表明，这种改变涉及亚细胞结构的形成和分泌两个方面。

相似文献

1
Carbon tetrachloride-induced inhibition of hepatocyte lipoprotein secretion: functional impairment of Golgi apparatus in the early phases of such injury.四氯化碳诱导的肝细胞脂蛋白分泌抑制：在此类损伤早期高尔基体的功能损害。
Life Sci. 1985 Feb 11;36(6):533-9. doi: 10.1016/0024-3205(85)90634-4.
2
Lipid peroxidation and covalent binding in the early functional impairment of liver Golgi apparatus by carbon tetrachloride.四氯化碳致肝高尔基体早期功能损伤中的脂质过氧化和共价结合
Cell Biochem Funct. 1990 Jan;8(1):1-10. doi: 10.1002/cbf.290080102.
3
Effects of CCl4 poisoning on metabolism of dolichol in rat liver microsomes and Golgi apparatus.四氯化碳中毒对大鼠肝微粒体和高尔基体中多萜醇代谢的影响。
Free Radic Res Commun. 1990;11(4-5):267-77. doi: 10.3109/10715769009088924.
4
Influence of lipid peroxidation on lipoprotein secretion by isolated hepatocytes.脂质过氧化对分离的肝细胞分泌脂蛋白的影响。
Lipids. 1981 Nov;16(11):823-9. doi: 10.1007/BF02535037.
5
Carbon tetrachloride-dependent inhibition of lipid secretion by isolated hepatocytes. Characterization and requirement for bioactivation.
Biochem Pharmacol. 1984 Aug 1;33(15):2419-23. doi: 10.1016/0006-2952(84)90713-5.
6
The effect of heparin on the metabolism of triglycerides by the liver.肝素对肝脏甘油三酯代谢的影响。
Biochem Pharmacol. 1970 Feb;19(2):411-20. doi: 10.1016/0006-2952(70)90196-6.
7
Evidence against involvement of calcium in carbon tetrachloride-dependent inhibition of lipid secretion by isolated hepatocytes.关于钙参与四氯化碳对分离的肝细胞脂质分泌的依赖性抑制作用的证据不足。
Biochem Pharmacol. 1984 Aug 1;33(15):2425-9. doi: 10.1016/0006-2952(84)90714-7.
8
The requirement of free fatty acids for the fatty liver of CCl4 intoxication.四氯化碳中毒性脂肪肝对游离脂肪酸的需求
Proc Soc Exp Biol Med. 1968 Mar;127(3):850-4. doi: 10.3181/00379727-127-32820.
9
[Hepatic synthesis of beta-lipoproteins in experimental carbon tetrachloride poisoning].[实验性四氯化碳中毒时肝脏中β-脂蛋白的合成]
Pathol Biol. 1968 Aug-Sep;16(15):735-8.
10
Effect of CCl4 intoxication on the synthesis of beta-lipoprotein fractions in rat liver.四氯化碳中毒对大鼠肝脏β-脂蛋白各组分合成的影响。
Clin Chim Acta. 1968 Mar;19(3):363-6. doi: 10.1016/0009-8981(68)90259-3.

引用本文的文献

1
Role of the sympathetic nervous system in carbon tetrachloride-induced hepatotoxicity and systemic inflammation.交感神经系统在四氯化碳诱导的肝毒性和全身炎症中的作用。
PLoS One. 2015 Mar 23;10(3):e0121365. doi: 10.1371/journal.pone.0121365. eCollection 2015.
2
Liver cell models in in vitro toxicology.体外毒理学中的肝细胞模型
Environ Health Perspect. 1998 Apr;106 Suppl 2(Suppl 2):511-32. doi: 10.1289/ehp.98106511.
3
Impairment of lipoglycoprotein metabolism in rat liver cells induced by 1,2-dichloroethane.1,2-二氯乙烷诱导大鼠肝细胞脂糖蛋白代谢受损。
Occup Environ Med. 1994 Apr;51(4):281-5. doi: 10.1136/oem.51.4.281.