Li Renjie, Li Jie, He Danni, Sui Yajuan, Liu Wenfen, Li Wentao, Meng Wenyi, Peng Jiahui, Xu Zuofeng
The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.
Abdom Radiol (NY). 2024 Dec 18. doi: 10.1007/s00261-024-04762-2.
To investigate whether a low-calorie, reduced-fat diet affects liver attenuation imaging (ATI) measurements.
A total of 320 participants were enrolled in this prospective study. They were randomly assigned to four groups: a fasting group, a postprandial 0.5-hour examination group, a postprandial 2-hour examination group, and a postprandial 4-hour examination group. All participants first underwent liver ATI examination in a fasting state. Those in the postprandial groups then consumed a low-calorie, reduced-fat diet before undergoing a second ATI examination at 0.5 h, 2 h, or 4 h after the meal. The ATI values were compared among the groups. The differences between postprandial and fasting ATI values were also analyzed for the postprandial groups. Additionally, the consistency of the grading diagnosis of hepatic steatosis between the postprandial and fasting states was evaluated in the postprandial groups.
The ATI values for the 0.5 h postprandial group, 2 h postprandial group, and 4 h postprandial group were not significantly different from those of the fasting group (P = 0.576, 0.471, and 0.992, respectively). No significant differences were noted in the ATI values recorded during the postprandial and fasting states within each of the postprandial groups (P = 0.573, 0.076, and 0.805, respectively). The kappa values for diagnostic consistency between the postprandial and fasting states across the three divergent criteria were 0.833-0.951, 0.812-0.855, and 0.737-0.862, respectively.
A low-calorie, reduced-fat diet does not significantly affect liver ATI measurements or the grading of hepatic steatosis. However, the lack of representation of older adults and populations with higher BMIs in this study may limit its generalizability, with the lack of external validation as a limitation. These issues should be tested and confirmed in further studies.
(ChiCTR2200062314, August 2022).
探讨低热量、低脂饮食是否会影响肝脏衰减成像（ATI）测量结果。
共有320名参与者纳入这项前瞻性研究。他们被随机分为四组：空腹组、餐后0.5小时检查组、餐后2小时检查组和餐后4小时检查组。所有参与者首先在空腹状态下接受肝脏ATI检查。餐后组的参与者随后食用低热量、低脂饮食，然后在餐后0.5小时、2小时或4小时接受第二次ATI检查。比较各组的ATI值。还分析了餐后组餐后和空腹ATI值之间的差异。此外，在餐后组中评估了餐后和空腹状态下肝脂肪变性分级诊断的一致性。
餐后0.5小时组、餐后2小时组和餐后4小时组的ATI值与空腹组相比无显著差异（P分别为0.576、0.471和0.992）。各餐后组在餐后和空腹状态下记录的ATI值也无显著差异（P分别为0.573、0.076和0.805）。在三种不同标准下，餐后和空腹状态之间诊断一致性的kappa值分别为0.833 - 0.951、0.812 - 0.855和0.737 - 0.862。
低热量、低脂饮食不会显著影响肝脏ATI测量结果或肝脂肪变性分级。然而，本研究中缺乏老年人和高BMI人群的代表性可能会限制其普遍性，且缺乏外部验证也是一个局限性。这些问题应在进一步研究中进行测试和确认。
（ChiCTR2200062314，2022年8月）
