Wei Xiao-Lian, Mo Song-Yi, Ali-Saeed Rola, Zeng Hong
School of Basic Medicine, Youjiang Medical University for Nationalities, Baise, 533000, Guangxi, People's Republic of China.
Department of Biochemistry, Faculty of Medicine, Bioscience, and Nursing, MAHSA University, 42610, Jenjarom, Selangor, Malaysia.
Curr Microbiol. 2024 Dec 18;82(1):45. doi: 10.1007/s00284-024-03999-w.
In recent years, exopolysaccharides (EPSs) from actinomycetes have become a significant focus of research due to their diverse biological activities, including antitumor, antiviral, and immunoregulatory effects. This article reviews recent advancements in the study of EPSs from actinomycetes, summarizing findings from existing literature on extraction methods, structural characteristics, and biological activities. Various extraction methods can impact the purity and quality of EPSs obtained from actinomycetes. In addition, EPSs produced by different species of actinomycetes exhibit diverse structures, leading to variations in their biological activities. Future research should focus on optimizing current extraction methods or developing new techniques, exploring the relationship between structural characteristics and biological activities of EPSs, and elucidating their molecular mechanisms of action. Such efforts are essential for the comprehensive study and potential applications of EPSs from actinomycetes.
近年来,放线菌产生的胞外多糖(EPSs)因其多样的生物活性,包括抗肿瘤、抗病毒和免疫调节作用,已成为研究的重要焦点。本文综述了放线菌胞外多糖研究的最新进展,总结了现有文献中关于提取方法、结构特征和生物活性的研究结果。各种提取方法会影响从放线菌获得的胞外多糖的纯度和质量。此外,不同种类放线菌产生的胞外多糖具有不同的结构,导致其生物活性存在差异。未来的研究应集中于优化现有提取方法或开发新技术,探索胞外多糖结构特征与生物活性之间的关系,并阐明其分子作用机制。这些努力对于放线菌胞外多糖的全面研究和潜在应用至关重要。