Nutrition Research Center, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Carbohydr Polym. 2019 Aug 1;217:79-89. doi: 10.1016/j.carbpol.2019.04.025. Epub 2019 Apr 20.
Several scientific evidences have revealed probiotics implications on human health. A wide range of lactic acid bacteria (LAB) have been extensively studied for their ability to produce extracellular polysaccharides (EPSs), which are repeating units of mono/oligosaccharides with various chemical compositions and properties. Despite the conventional belief regarding probiotics that states bacteria must be alive to exert their beneficial effects, mounting evidence opened up new perspectives on health-promoting effects of bacterial-derived molecules/metabolites. Employing EPSs seems safer alternative in complicated disorders like cancer and immune related diseases. EPSs have potential applications in textiles, cosmetology, wastewater treatment, food, and pharmaceutical industries, but little is known about their function therefore the present review aims to discuss the health-promoting properties of EPSs produced by LAB. Antioxidant, antiviral, antitumor and immunomodulating activity, with focus on the mechanisms involved, are discussed in the study. Ever-growing number of researches indicate that EPSs beneficiary effects have a promising future ahead.
已有多项科学证据表明益生菌对人类健康的影响。人们广泛研究了多种乳酸菌（LAB），因为它们具有产生胞外多糖（EPS）的能力，EPS 由具有不同化学组成和性质的单/寡糖重复单元组成。尽管人们普遍认为益生菌必须是活的才能发挥其有益作用，但越来越多的证据为细菌衍生分子/代谢物的促进健康的作用开辟了新的视角。在癌症和免疫相关疾病等复杂疾病中，使用 EPS 似乎是一种更安全的选择。EPS 在纺织、化妆品、废水处理、食品和制药等行业具有潜在的应用，但人们对其功能知之甚少，因此本综述旨在讨论 LAB 产生的 EPS 的促进健康的特性。本研究讨论了抗氧化、抗病毒、抗肿瘤和免疫调节活性，重点讨论了相关机制。越来越多的研究表明，EPS 的有益作用具有广阔的前景。
