Khan Mohammed Shareef, Murthy Aditya, Ahmed Tausif
Biopharmaceutics - Biopharmaceutics and Bioequivalence, Global Clinical Management, Dr. Reddy's Laboratories Ltd, Hyderabad, India.
Biopharmaceutics and Bioanalytical - Global Clinical Management, Dr. Reddy's Laboratories Ltd, Hyderabad, India.
AAPS PharmSciTech. 2024 Dec 17;26(1):14. doi: 10.1208/s12249-024-03001-7.
This review paper discusses the key aspects of ocular biopharmaceutics, with emphasis on the crucial role played by ocular compartmental modelling and simulation in deciphering physiological conditions related to various eye diseases. It describes eye's intricate structure and function and the need for precise and targeted drug delivery systems to address prevalent eye conditions. The review categorizes and discusses various formulations employed in ocular drug delivery, delineating their respective advantages and limitations. Additionally, it probes the challenges inherent in diverse routes of drug administration for ocular therapies and provides insights into the complexities of achieving optimal drug concentrations at the target site within the eye. The central theme of this work is the ocular compartmental modelling and simulations. Hence, this works discusses on the nuanced understanding of physiological conditions within the eye, drug distribution, drug release kinetics, and key considerations for ocular compartmental modelling and simulations. By combining information from various sources, this review aims to serve as a comprehensive reference for researchers, clinicians, and pharmaceutical developers. It covers the multifaceted landscape of ocular biopharmaceutics and the transformative impact of modelling and simulation in optimizing ocular drug delivery strategies.
这篇综述论文讨论了眼部生物药剂学的关键方面，重点强调了眼部房室建模与模拟在解读与各种眼部疾病相关的生理状况中所起的关键作用。它描述了眼睛复杂的结构和功能，以及为应对常见眼部疾病而开发精确且靶向给药系统的必要性。该综述对眼部给药中使用的各种制剂进行了分类和讨论，阐述了它们各自的优缺点。此外，它探讨了眼部治疗中不同给药途径所固有的挑战，并深入分析了在眼内靶部位实现最佳药物浓度的复杂性。这项工作的核心主题是眼部房室建模与模拟。因此，本文讨论了对眼内生理状况、药物分布、药物释放动力学以及眼部房室建模与模拟的关键考虑因素的细微理解。通过整合来自各种来源的信息，本综述旨在为研究人员、临床医生和制药开发者提供全面的参考。它涵盖了眼部生物药剂学的多方面领域，以及建模与模拟在优化眼部给药策略方面的变革性影响。
