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SGLT2 Inhibition Induces Cardioprotection by Increasing Parasympathetic Activity.

作者信息

Basalay Maryna V, Korsak Alla, He Zhenhe, Gourine Alexander V, Davidson Sean M, Yellon Derek M

机构信息

The Hatter Cardiovascular Institute, University College London, United Kingdom (M.V.B., Z.H., S.M.D., D.M.Y.).

Department of Neuroscience, Physiology and Pharmacology, Centre for Cardiovascular and Metabolic Neuroscience, University College London, United Kingdom (A.K., A.V.G.).

出版信息

Circ Res. 2025 Jan 17;136(2):229-231. doi: 10.1161/CIRCRESAHA.124.324708. Epub 2024 Dec 17.

DOI:10.1161/CIRCRESAHA.124.324708
PMID:39690446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11741129/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a9d/11741129/446cadfc09aa/res-136-229-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a9d/11741129/446cadfc09aa/res-136-229-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a9d/11741129/446cadfc09aa/res-136-229-g001.jpg

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本文引用的文献

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Vago-splenic signal transduction of cardioprotection in humans.人类心脏保护作用的迷走-脾信号转导。
Eur Heart J. 2024 Sep 7;45(34):3164-3177. doi: 10.1093/eurheartj/ehae250.
2
Immediate and sustained increases in the activity of vagal preganglionic neurons during exercise and after exercise training.运动中和运动训练后迷走节前神经元活动的即时和持续增加。
Cardiovasc Res. 2023 Oct 24;119(13):2329-2341. doi: 10.1093/cvr/cvad115.
3
Sodium Glucose Cotransporter-2 Inhibitor Empagliflozin Reduces Infarct Size Independently of Sodium Glucose Cotransporter-2.
Circ Res. 2025 May 23;136(11):1306-1334. doi: 10.1161/CIRCRESAHA.124.325488. Epub 2025 May 22.
4
Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th Hatter Cardiovascular Institute workshop.器官间通讯:心脏保护和神经保护的途径与靶点。第12届哈特心血管研究所研讨会报告。
Basic Res Cardiol. 2025 Apr;120(2):287-299. doi: 10.1007/s00395-024-01094-6. Epub 2024 Dec 16.
钠葡萄糖协同转运蛋白2抑制剂恩格列净可独立于钠葡萄糖协同转运蛋白2减少梗死面积。
Circulation. 2023 Jan 17;147(3):276-279. doi: 10.1161/CIRCULATIONAHA.122.061688.
4
SGLT-2 inhibitors in patients with heart failure: a comprehensive meta-analysis of five randomised controlled trials.钠-葡萄糖协同转运蛋白 2 抑制剂在心力衰竭患者中的应用:五项随机对照试验的综合荟萃分析。
Lancet. 2022 Sep 3;400(10354):757-767. doi: 10.1016/S0140-6736(22)01429-5. Epub 2022 Aug 27.
5
Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection.心脏保护临床前和临床研究中严谨性与可重复性的实用指南。
Basic Res Cardiol. 2018 Aug 17;113(5):39. doi: 10.1007/s00395-018-0696-8.