Ceratinadin G, a new psammaplysin derivative possessing a cyano group from a sponge of the genus .

A new psammaplysin derivative, ceratinadin G (), was obtained from the Okinawan marine sponge sp., and the gross structure was clarified through spectroscopic and spectrometric analyses. The absolute configuration of compound was established by comparing its NMR and ECD data with those of the known psammaplysin derivative, psammaplysin F (). Ceratinadin G () is a rare nitrile containing a cyano group as aminoacetonitrile, and is the first psammaplysin derivative possessing a cyano group. In vitro assays indicated that compound displayed moderate cytotoxicity against L1210 murine leukemia cells and KB epidermoid carcinoma cells.