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角海绵素G，一种来自某属海绵的具有氰基的新沙海葵毒素衍生物。

Ceratinadin G, a new psammaplysin derivative possessing a cyano group from a sponge of the genus .

作者信息

Kurimoto Shin-Ichiro, Inoue Kouta, Ohno Taito, Kubota Takaaki

机构信息

Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-naka, Kita-ku, Okayama 700-8530, Japan.

Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan.

出版信息

Beilstein J Org Chem. 2024 Dec 9;20:3215-3220. doi: 10.3762/bjoc.20.267. eCollection 2024.

DOI:10.3762/bjoc.20.267
PMID:39691216
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11650486/
Abstract

A new psammaplysin derivative, ceratinadin G (), was obtained from the Okinawan marine sponge sp., and the gross structure was clarified through spectroscopic and spectrometric analyses. The absolute configuration of compound was established by comparing its NMR and ECD data with those of the known psammaplysin derivative, psammaplysin F (). Ceratinadin G () is a rare nitrile containing a cyano group as aminoacetonitrile, and is the first psammaplysin derivative possessing a cyano group. In vitro assays indicated that compound displayed moderate cytotoxicity against L1210 murine leukemia cells and KB epidermoid carcinoma cells.

摘要

一种新的沙海葵毒素衍生物，角沙海葵毒素G（），是从冲绳海洋海绵属中获得的，其总体结构通过光谱和光谱分析得以阐明。通过将其核磁共振（NMR）和电子圆二色光谱（ECD）数据与已知的沙海葵毒素衍生物沙海葵毒素F（）的数据进行比较，确定了化合物的绝对构型。角沙海葵毒素G（）是一种罕见的腈类化合物，含有作为氨基乙腈的氰基，是首个含有氰基的沙海葵毒素衍生物。体外试验表明，该化合物对L1210小鼠白血病细胞和KB表皮样癌细胞显示出中等程度的细胞毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3523/11650486/d2eb39a3969d/Beilstein_J_Org_Chem-20-3215-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3523/11650486/9e134a745806/Beilstein_J_Org_Chem-20-3215-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3523/11650486/198f28382cd7/Beilstein_J_Org_Chem-20-3215-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3523/11650486/d2eb39a3969d/Beilstein_J_Org_Chem-20-3215-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3523/11650486/9e134a745806/Beilstein_J_Org_Chem-20-3215-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3523/11650486/198f28382cd7/Beilstein_J_Org_Chem-20-3215-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3523/11650486/d2eb39a3969d/Beilstein_J_Org_Chem-20-3215-g004.jpg

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