Siqueira Rubens Camargo, Pinho Tainara Souza, Brandão Cinara Cássia
Rubens Siqueira Research Center, São Jose do Rio Preto, Brazil.
Faculty of Medicine of São Jose do Rio Preto-FAMERP, São Jose do Rio Preto, Brazil.
Clin Ophthalmol. 2024 Dec 13;18:3715-3724. doi: 10.2147/OPTH.S483722. eCollection 2024.
To assess the short-term effects of Multiwavelength Photobiomodulation (LumiThera Valeda Light Delivery System) on retinal functional behavior in patients with retinitis pigmentosa (RP).
Twelve RP patients (24 eyes) underwent treatment involving nine photobiomodulation (PBM) sessions using the Valeda system, which emits three distinct wavelengths within the yellow (590 nm; 4 mW/cm2), red (660 nm; 65 mW/cm2), and near-infrared (NIR) (850 nm; 0.6 mW/cm2) spectrum. All evaluations were conducted four weeks post-therapy. The treated eye was compared with baseline (pre-therapy). Following nine PBM sessions, assessments included best-corrected visual acuity (BCVA), retinal sensitivity, and characteristics of the correction area via fundus automated perimetry using the Compass system. Additionally, a functional and structural assessment of the retina was performed using multifocal electroretinography (ERG), optical coherence tomography (OCT), fluorescence retinography (FR), and autofluorescence (AF). Statistical analysis employed the Student's -test for paired samples at a 95% confidence level (p-value ≤ 0.05).
LogMAR-based visual acuity assessment demonstrated an improvement in mean value from 0.62 to 0.53 logMAR, with a statistically significant p-value of 0.001. Visual field examination, based on mean deviation (MD), pattern standard deviation (PSD), and fundal perimeter deviation index (FPDI) parameters, showed improvement from -19.87 dB to -19.45 dB, 9.77 dB to 9.76 dB, and 37% to 39%, respectively, although with non-significant p-values of 0.366, 0.446, and 0.245, respectively. No adverse effects or abnormalities in optical coherence tomography (OCT) and electroretinogram (ERG) were observed during the follow-up period.
In this short-term study, PBM appeared to have the potential to enhance BCVA and fundus automated perimeter in RP patients without causing significant adverse events. However, further assessment with a larger patient cohort and longer follow-up is warranted to ascertain the efficacy of this technique in these patients.
评估多波长光生物调节疗法（LumiThera Valeda光传递系统）对视网膜色素变性（RP）患者视网膜功能行为的短期影响。
12例RP患者（24只眼）接受了治疗，使用Valeda系统进行了9次光生物调节（PBM）治疗，该系统在黄色（590 nm；4 mW/cm2）、红色（660 nm；65 mW/cm2）和近红外（NIR）（850 nm；0.6 mW/cm2）光谱范围内发射三种不同波长的光。所有评估均在治疗后四周进行。将治疗后的眼睛与基线（治疗前）进行比较。在进行9次PBM治疗后，评估包括最佳矫正视力（BCVA）、视网膜敏感度，以及使用Compass系统通过眼底自动视野计测量的矫正区域特征。此外，还使用多焦视网膜电图（ERG）、光学相干断层扫描（OCT）、荧光视网膜造影（FR）和自发荧光（AF）对视网膜进行了功能和结构评估。统计分析采用配对样本的学生t检验，置信水平为95%（p值≤0.05）。
基于LogMAR的视力评估显示，平均值从0.62 LogMAR提高到了0.53 LogMAR，p值为0.001，具有统计学意义。基于平均偏差（MD）、模式标准差（PSD）和眼底周长偏差指数（FPDI）参数的视野检查显示，分别从-19.87 dB提高到-19.45 dB、从9.77 dB提高到9.76 dB、从37%提高到39%，尽管p值分别为0.366、0.446和0.245，无统计学意义。在随访期间，未观察到光学相干断层扫描（OCT）和视网膜电图（ERG）有不良反应或异常。
在这项短期研究中，PBM似乎有可能提高RP患者的BCVA和眼底自动视野，且不会引起明显的不良事件。然而，需要更大规模的患者队列和更长时间的随访进行进一步评估，以确定该技术在这些患者中的疗效。
